抗骨增生胶囊联合玻璃酸钠和氨基葡萄糖胶囊治疗膝骨关节炎的临床研究

目的探讨抗骨增生胶囊联合玻璃酸钠和氨基葡萄糖胶囊治疗膝骨关节炎的临床疗效。方法选取2012年4月—2015年4月在四川省骨科医院接受治疗的膝骨关节炎患者100例,根据治疗方案的差别分为对照组和治疗组,每组各50例,对照组患者关节腔注射玻璃酸钠注射液,2 m L/次,1次/周;同时口服盐酸氨基葡萄糖胶囊,2粒/次,3次/d。治疗组在对照组的基础上口服抗骨增生胶囊,5粒/次,3次/d。两组患者均连续治疗6个月。观察两组的临床疗效,同时比较两组治疗前后WOMAC评分、肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β)、软骨寡聚基质蛋白(COMP)、基质金属蛋白酶-9(MMP-9)、NO、丙二醛(MDA)和超氧化物歧化酶(SOD)水平的变化情况。结果治疗后,对照组和治疗组的总有效率分别为84.00%、96.00%,两组比较差异有统计学意义(P0.05)。治疗后,两组患者疼痛评分、关节僵硬评分、日常活动评分和综合评分均较治疗前显著降低,同组治疗前后差异具有统计学意义(P0.05);且治疗组WOMAC评分减少程度优于对照组,两组比较差异有统计学意义(P0.05)。治疗后,两组TNF-α、IL-1β、COMP及MMP-9水平显著降低,同组治疗前后差异有统计学意义(P0.05);且治疗组的降低程度优于对照组,两组比较差异有统计学意义(P0.05)。治疗后,两组患者血清NO、MDA水平显著降低,而SOD水平则升高,同组治疗前后差异具有统计学意义(P0.05);且治疗组这些观察指标的改善程度优于对照组,两组比较差异具有统计学意义(P0.05)。结论抗骨增生胶囊联合玻璃酸钠和氨基葡萄糖胶囊治疗膝骨关节炎疗效显著,可明显改善患者临床症状,降低血清炎性水平,具有一定的临床推广应用价值。

Clinical study on Kanggu Zengsheng Capsules combined with sodium hyaluronate and Glucosamine Capsules in treatment of knee osteoarthritis

Objective To investigate the clinical efficacies of Kanggu Zengsheng Capsules combined with sodium hyaluronate and Glucosamine Capsules in treatment of knee osteoarthritis. Methods Patients (100 cases) with knee osteoarthritis in Sichuan Province Orthopedic Hospital from April 2012 to April 2015 were divided into control and treatment groups based on different treatments, and each group had 50 cases. The patients in the control group were intra-articular injection of Sodium Hyaluronate Injection, 2 mL/time, once weekly. And they were po administered with Glucosamine Hydrochloride Capsules, 2 grains/time, three times daily. The patients in the treatment group were po administered with Kanggu Zengsheng Capsules, 5 grains/time, three times daily. The patients in two groups were treated for 6 months. After treatment, clinical efficacies were evaluated. And WOMAC scores in two groups were recorded. In the same time, the levels of TNF-α, IL-1β, COMP, MMP-9, NO, MDA, and SOD in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 84.00% and 96.00%, respectively, and there were differences between two groups (P<0.05). After treatment, pain scores, joint stiffness scores, daily activity scores, and comprehensive scores in two groups were lower than those in the same group before treatment, and there were differences in the same group (P<0.05). And the decrease degree of WOMAC scores in the treatment group was better than that in the control group, with significant difference between two groups (P < 0.05). After treatment, TNF-α, IL-1β, COMP, and MMP-9 levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). These observational indexes in treatment group were lower than those in control group, with significant difference between two groups (P<0.05). After treatment, serum NO and MDA levels in two groups were decreased, and SOD level was increased, and the difference was statistically significant in the same group (P<0.05). And the improvement of these observational indexes in the treatment group was better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Kanggu Zengsheng Capsules combined with sodium hyaluronate and Glucosamine Capsules have clinical curative effect in treatment of knee osteoarthritis, can significantly improve the clinical symptoms and reduce the serum inflammatory levels, which has a certain clinical application value.