T2 relaxometry of brain in myotonic dystrophy |
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Authors: | A Di Costanzo F Di Salle L Santoro V Bonavita G Tedeschi |
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Institution: | (1) Institute of Neurological Sciences, Second University of Naples, Via S Pansini 5, 80 131 Naples, Italy e-mail: alfonso.dicostanzo@unina2.it Fax: + 39-81-5 66 67 87 Tel.: + 39-81-5 46 44 02, IT;(2) Department of Biomorphological and Functional Sciences, University “Federico II”, Naples, Italy, IT;(3) Department of Neurological Sciences, University “Federico II”, Naples, Italy, IT |
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Abstract: | We investigated the nature and extent of brain involvement in myotonic dystrophy (DM), examining possible T2 relaxation abnormalities
in the brain of 20 patients with adult-onset DM and 20 sex- and age-matched normal controls. Brain MRI was performed at 0.5
T, and T2 values were calculated from signal intensity in two echoes. Regions of interest included: frontal, parietal, temporal,
occipital and callosal (rostral and splenial) normal-appearing white matter; frontal, occipital, insular and hippocampal cortex;
caudate nucleus, putamen, globus pallidus and thalamus. All white-matter and occipital and right frontal cortex regions showed
a significantly longer T2 in the patients. Multiple regression analysis, including grey- and white-matter T2 as dependent
variables, plus age at onset and at imaging, disease duration, muscular disability, brain atrophy and CTG trinucleotide repeats
as independent variables, revealed that only white-matter T2 elongation and disease duration correlated positively. White-matter
involvement in DM is more extensive than previously reported by MRI and neuropathological studies and seems to be progressive
in the course of disease.
Received: 31 May 2000 Accepted: 27 July 2000 |
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Keywords: | Myotonic dystrophy Magnetic resonance imaging |
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