Amphetamine abolishes REM sleep rebound in rats: effect of a single injection

Rats implanted with electrodes for polygraphic recording were deprived of REM sleep for 24 h. Following REM deprivation animals were injected with d-amphetamine (3 mg/kg, i.p.) and were polygraphically recorded for 48 h. The results show that administration of amphetamine abolished the initial 12 h of REM sleep rebound and that this loss of REM sleep was not regained during the entire 0–48 post-REM deprivation period.