晚期霍奇金病128例临床总结分析

目的 探讨晚期霍奇金病的合理治疗方法。方法 对１２８例晚期霍奇金病的治疗结果进行了总结和分析。结果 总有效率９６．１％（１１２／１２７），其中完全缓解（ＣＲ）率８．５％，化放疗组、单化疗组和单放疗组的ＣＲ率分别为６９．７％、５８．３％和１００％。全组１，３，５，１０年生存率分别为．４％、７０．３％、５６．８％和５２．４％。生存率分析显示，临床Ⅲ期，无全身症状、无巨块型、淋巴细胞为主型和结节经型、化

Treatment of advanced Hodgkin's disease: an analysis of 128 cases]

OBJECTIVE: To explore the rational treatment for advanced Hodgkin's disease. METHODS: A total of 128 patients with advanced Hodgkin's disease was included in this study. They could be divided into 3 groups according to the treatment they received. Patients in group 1 (n = 99) were treated by combination chemotherapy plus radiotherapy. Patients in group 2 (n = 24) were treated by chemotherapy alone. The remaining 5 patients in group 3 were treated by radiotherapy alone. The chemotherapeutic regimens used were MOPP, MOPP alternating with CHOP, or with ABVD. RESULTS: The overall response rate of 127 evaluable patients was 96.1%. The overall 1-, 3-, 5, and 10-year survival rate was 91.4%, 70.3%, 56.8% and 52.4%, respectively. The complete response (CR) rate in the 3 groups of patients was 69.7%, 58.3% and 100%, respectively. Patients in clinical stage III with no bulky mass, no systemic symptoms, and their tumor was predominantly of lymphocytic or nodular sclerotic type had better long term survival than those in clinical stage IV with bulky mass, systemic symptoms, and with lymphocyte depleting, mixed cellular tumor. Better long term survival was seen in patients who showed complete response to combined chemotherapy and radiotherapy. At least 6 cycles of chemotherapy were needed. CONCLUSION: Combination chemotherapy plus radiotherapy is effective in the treatment of advanced Hodgkin's disease.