| 流化床包衣法制备芍药总苷缓释微丸的研究 |
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| 引用本文： | 陈丽华,徐德生,冯 怡,洪燕龙,汪益涵.流化床包衣法制备芍药总苷缓释微丸的研究[J].医学教育探索,2009,40(3):379-383. |
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| 作者姓名： | 陈丽华 徐德生 冯 怡 洪燕龙 汪益涵 |
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| 作者单位： | 1.江西中医学院 现代中药制剂教育部重点实验室，江西 南昌 330004； 2.上海中医药大学附属曙光医院， 上海 200021； 3.上海中医药大学，上海 201203 |
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| 基金项目： | 上海市重点学科建设项目（T0301）；上海市科委项目（04DZ19841）；高等学校博士学科点专项科研基金资助项目（20060268009） |
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| 摘 要： | 目的 应用挤出滚圆法制备芍药总苷速释微丸，用Eudragit RS 100作为包衣材料，制备芍药总苷缓释微丸。方法 采用mini Glatt流化床底喷包衣法制备缓释微丸，对其包衣工艺及处方进行单因素考察，评价微丸的粉体学性质和体外释放行为。结果 当聚合物包衣增质量为6%，增塑剂用量为10%时，药物具有明显的缓释作用，体外释放曲线符合Peppas和Higuchi方程。结论 制备的芍药总苷缓释微丸具备较理想的缓释效果。
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| 关 键 词： | 芍药总苷缓释微丸 Eudragit RS 100 缓释微丸 释放度 |
Preparation of total glucosides in paeony sustained-release pellets by fluidized bed coating method |
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| CHEN Li-hu,XU De-sheng,FENG Yi,HONG Yan-long,WANG Yi-han.Preparation of total glucosides in paeony sustained-release pellets by fluidized bed coating method[J].Researches in Medical Education,2009,40(3):379-383. |
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| Authors: | CHEN Li-hu XU De-sheng FENG Yi HONG Yan-long WANG Yi-han |
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| Institution: | 1. Key Laboratory for Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China; 2. Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China; 3. Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China |
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| Abstract: | Objective To prepare totel glucosides in paeony (TGP) pellets by extrusion-spheronization and to optimize the formulation of TGP sustained-release pellets coated with Eudragit RS 100. Methods The TGP sustained-release pellets were prepared by mini Glatt fluidized bed coating method. The factors to influence the drug release behaviors and their properties were evaluated. Results The optimal TGP sustained-release pellet was shown significant sustained-releasing at the loading weight of copolymers of 6% and the plasticizer concentration of 10%. And the curves of cumulative drug release were fit for Peppas and Higuchi equation. Conclusion The pellets showed an obviously sustained-release effect. |
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