PI3K activation is associated with intracellular sodium/iodide symporter protein expression in breast cancer |
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| Authors: | Katherine AB Knostman James A McCubrey Carl D Morrison Zhaoxia Zhang Charles C Capen Sissy M Jhiang |
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| Affiliation: | (1) Department of Veterinary Biosciences, The Ohio State University, 43210 Columbus, Ohio, USA;(2) Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, North Carolina, USA;(3) Department of Pathology, The Ohio State University, 43210 Columbus, Ohio, USA;(4) Ohio State Biochemistry Program, The Ohio State University, 43210 Columbus, Ohio, USA;(5) Department of Physiology and Cell Biology, The Ohio State University, 43210 Columbus, Ohio, USA |
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| Abstract: | Background The sodium/iodide symporter (NIS) is a membrane glycoprotein mediating active iodide uptake in the thyroid gland and is the molecular basis for radioiodide imaging and therapeutic ablation of thyroid carcinomas. NIS is expressed in the lactating mammary gland and in many human breast tumors, raising interest in similar use for diagnosis and treatment. However, few human breast tumors have clinically evident iodide uptake ability. We previously identified PI3K signaling as important in NIS upregulation in transgenic mouse models of breast cancer, and the PI3K pathway is commonly activated in human breast cancer. |
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