| MicroRNA-494参与多种疾病发生发展的分子机制研究进展 |
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| 引用本文： | 李广文,赵海苹,罗玉敏. MicroRNA-494参与多种疾病发生发展的分子机制研究进展[J]. 中国病理生理杂志, 2016, 32(10): 1909-1915. DOI: 10.3969/j.issn.1000-4718.2016.10.029 |
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| 作者姓名： | 李广文 赵海苹 罗玉敏 |
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| 作者单位： | 首都医科大学宣武医院脑血管病研究室, 北京 100053 |
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| 基金项目： | 国家自然科学基金资助项目（No.81571280；No.81271461） |
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| 摘 要： | 正微小RNA(microRNA,miRNA,miR)是一种由20~22个核苷酸组成的内源性非编码小分子单链RNA,它可以在后转录水平通过以完全互补或不完全互补的形式与mRNA的3’UTR区结合调控细胞增殖、分化及凋亡等多个生理病理过程~([1])。其中,miR-494是一种来源于染色体14q32.31的miRNA~([2])。近年来的研究发现miR-494参与人体多个
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| 关 键 词： | 微小RNA-494 肿瘤 缺血 缺氧 |
| 收稿时间： | 2016-06-30 |
Progress in functions of microRNA-494 and related mechanism |
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| LI Guang-wen,ZHAO Hai-ping,LUO Yu-min. Progress in functions of microRNA-494 and related mechanism[J]. Chinese Journal of Pathophysiology, 2016, 32(10): 1909-1915. DOI: 10.3969/j.issn.1000-4718.2016.10.029 |
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| Authors: | LI Guang-wen ZHAO Hai-ping LUO Yu-min |
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| Affiliation: | Cerebrovascular Diseases Research Institute and Department of Neurology, Xuan Wu Hospital of Capital Medical University, Beijing 100053, China |
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| Abstract: | MicroRNA-494 (miR-494) is one of the microRNAs from 14q32.31 miR-gene cluster. Recently, miR-494 was found to closely relate with tumors and other diseases. This article reviews the expression changes, roles and possible regulatory mechanisms of miR-494 in multiple tumors and other hypoxia/ischemia diseases. Recent studies demonstrate that the expression of miR-494 is affected by many factors, and miR-494 could be a biomarker of diagnosis, staging and prognosis in tumors and other diseases, and a target of therapy in future. |
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| Keywords: | MicroRNA-494 Tumor Ischemia Hypoxia |
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