| 蛋白质二硫键异构酶A3——疾病治疗的新靶点 |
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| 引用本文： | 胡玥,陶丽媛,吕宾.蛋白质二硫键异构酶A3——疾病治疗的新靶点[J].中国病理生理杂志,2015,31(6):1145-1149. |
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| 作者姓名： | 胡玥 陶丽媛 吕宾 |
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| 作者单位： | 浙江中医药大学附属第一医院消化科, 浙江 杭州 310006 |
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| 基金项目： | 国家自然科学基金资助项目(No.81170348);浙江省自然科学基金资助项目(No.LZ12H03001);高等学校博士学科点专项科研基金资助项目(No.722212A001) |
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| 摘 要： | <正>蛋白质二硫键异构酶A3(protein disulfide isomerase A3,PDIA3),又称ERp57或ERp57/GRP58,是蛋白质二硫键异构酶(protein disulfide isomerase,PDI)家族的一员,具有催化内质网中蛋白质二硫键形成、氧化还原及异构化的作用。Bennett等1]于1988年首次从不同物种中分离出PDIA3基因的互补DNA编码链,诸多研究显示其氨基酸序列
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| 收稿时间： | 2015-02-15 |
PDIA3: a new therapeutic target of diseases |
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| HU Yue,TAO Li-yuan,L&#,Bin.PDIA3: a new therapeutic target of diseases[J].Chinese Journal of Pathophysiology,2015,31(6):1145-1149. |
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| Authors: | HU Yue TAO Li-yuan L&# Bin |
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| Institution: | Department of Gastroenterology, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, China |
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| Abstract: | Protein disulfide isomerase A3 (PDIA3) is a member of protein disulphide isomerase family and widely exists in endoplasmic reticulum, cell surface, nucleus and mitochondria. PDIA3 promotes the glycoprotein folding and quality control in the endoplasmic reticulum and is also a key molecular of major histocompatibility complex class I molecules assembly. In addition, PDIA3 is involved in the cell signal transduction and plays an important role in a variety of disease development. Therefore, this paper talks about the function of PDIA3, the relationship between disease and PDIA3 as well as its clinical outlook. |
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