血清ACE2水平在冠心病发生发展中的变化

目的:通过检测血清血管紧张素转换酶2(ACE2)水平,分析ACE2与冠心病(CHD)不同病程之间的相关性,探讨其在CHD发生发展中的变化规律。方法:选取非CHD对照组样本85例,CHD样本174例,并按照冠状动脉狭窄严重程度分成轻度(50%)狭窄组(ls-CHD组)、中度(50%~75%)狭窄组(ms-CHD组)和严重(≥75%)狭窄组(ss-CHD组)。通过ELISA检测所有样本血清中ACE2水平,统计分析CHD不同病程下的ACE2水平,从而探讨血清ACE2水平与CHD发生发展间的关系。结果:ls-CHD、ms-CHD和ss-CHD组血清ACE2水平均高于非CHD组,并且随着冠状动脉狭窄严重程度的加深而上升。男性血清ACE2水平要比女性的高。单一性别内,ls-CHD、ms-CHD和ss-CHD组血清ACE2水平均高于非CHD组,并有显著性差异。回归分析发现性别、糖尿病、CHD与血清ACE2水平相关,并且性别和CHD是血清ACE2水平的独立影响因素。结论:男性血清ACE2水平高于女性;与非CHD患者相比,CHD患者血清ACE2水平升高;在CHD发生发展过程中,血清ACE2水平随CHD病情的恶化而持续升高。

Change of ACE2 level in serum during development of coronary heart disease

AIM: To analyze the correlation between serum angiotensin-converting enzyme 2 (ACE2) levels and different stages of coronary heart disease (CHD), and to explore the change of serum ACE2 level during the development of CHD.METHODS: The control group included 85 non-CHD samples, and 174 CHD samples were divided into light stenosis (ls-CHD, stenosis degree <50%) group, moderate stenosis (ms-CHD, stenosis degree 50%~75%) group and severe stenosis (ss-CHD, stenosis degree ≥ 75%) group. The ACE2 level in each serum sample was detected by ELISA. The relationship between the ACE2 level and the development of coronary heart disease was explored by statistical analysis of serum ACE2 levels in different stages of CHD.RESULTS: The serum ACE2 levels in ls-CHD group, ms-CHD group and ss-CHD group were all higher than that in control group. The more severe the coronary artery stenosis existed, the higher the ACE2 level was observed. The serum ACE2 level in the males was higher than that in the females. In a single sex, the serum ACE2 levels in ls-CHD group, ms-CHD group and ss-CHD group were higher than that in control group with significant differences. Regression analysis found that sex, diabetes and CHD were associated with the serum ACE2 levels. Among them, sex and CHD were the independent factors to affect serum ACE2 levels.CONCLUSION: The serum ACE2 level of males was higher than that of females. Compared with the non-CHD samples, the serum ACE2 level of CHD patients was higher than that of the non-CHD samples. During the development of coronary heart disease, the serum ACE2 level increased constantly.