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| 牛磺酸上调基因1对肿瘤发生发展的调控作用 | |
| 引用本文： | 姜兴明,王志东,李景林,郑汪洋,李正龙,李鑫恒,崔云甫.牛磺酸上调基因1对肿瘤发生发展的调控作用[J].中国病理生理杂志,2017,33(7):1332-1337. |
| 作者姓名： | 姜兴明 王志东 李景林 郑汪洋 李正龙 李鑫恒 崔云甫 |
| 作者单位： | 哈尔滨医科大学附属第二医院胆胰外科, 黑龙江 哈尔滨 150086 |
| 基金项目： | 国家自然科学基金资助项目（No.81602088）；黑龙江省卫生计生委科研课题资助项目（No.2016049）；黑龙江省博士后资助课题（No.LBH-Z16096）；哈尔滨医科大学创新科学研究基金资助项目（No.2016LCZX09） |
| 摘 要： | <正>基因的失调控(异常表达)是肿瘤发生发展的重要原因(诱因)业已被学术界所公认,而在这一过程中非编码RNA(non-coding RNA,ncRNA)起到了极为重要的调控作用~(1-2])。小RNA(small RNA;包括微小RNA,microRNA,miRNA,miR)和长链非编码RNA(long non-coding RNA,lncRNA)均属于ncRNA~(3-4])。 |
| 关 键 词： | 长链非编码RNA 牛磺酸上调基因1 肿瘤发生 |
| 收稿时间： | 2017-01-09 |
Regulatory effects of taurine up-regulated gene 1 on tumorigenesis |
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| JIANG Xing-ming,WANG Zhi-dong,LI Jing-lin,ZHENG Wang-yang, LI Zheng-long,LI Xin-heng,CUI Yun-fu.Regulatory effects of taurine up-regulated gene 1 on tumorigenesis[J].Chinese Journal of Pathophysiology,2017,33(7):1332-1337. |
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| Authors: | JIANG Xing-ming WANG Zhi-dong LI Jing-lin ZHENG Wang-yang LI Zheng-long LI Xin-heng CUI Yun-fu |
| Institution: | Department of Biliary-pancreatic Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China |
| Abstract: | It has been estimated that approximately 75% of the human genome is transcribed into RNA,74% of which would be transcribed into non-coding RNA (ncRNA).The ncRNA can be divided into 2 major groups including small RNA and long non-coding RNA (lncRNA).There is increasing evidence that the dysregulation of lncRNA is closely associated with the occurrence and progression of many tumors.The lncRNA taurine up-regulated gene 1(TUG1) is originally detected in a genomic screen for genes in response to taurine treatment of developing mouse retinal cells.According to research reports,dysregulation of TUG1 participates in the progression of a variety of tumors.Therefore,the regulatory effects of lncRNA TUG1 on tumorigenesis are summarized in this article. |
| Keywords: | Long non-coding RNA Taurine up-regulated gene 1 Tumorigenesis |
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