胃肠道Cajal间质细胞起搏功能的研究进展

正正常的胃肠运动功能依赖于节律性的胃肠蠕动,这种规律性的蠕动目前主要认为与肠神经系统及众多的神经递质有关,但其具体的调控机制目前尚有争议,主要争论的焦点在于肠神经系统所释放的神经递质是否直接作用于平滑肌细胞~(1-2])。近年来,越来越多的研究发现,Cajal间质细胞(interstitial cells of Cajal,ICC)在胃肠动力调节方面扮演着至关重要的作用~(3])。因此,本文拟就从生理结构基础、起

Research progress on pacemaker function of interstitial cells of Cajal in gastrointestinal tract

Interstitial cells of Cajal (ICC) is the pacemaker in the gastrointestinal tract, which is closely associated with the formation of slow wave and the regulation of gastrointestinal motility. As the pacemaker of gastrointestinal tract, the activation of pacing signal is triggered by the local calcium oscillation in the ICC. The change of calcium concentration can activate many relevant ion channels, such as NSCC, ANO1, VGCC, HCN channels and potassium channels, which can generate a large number of pacing current to form the slow wave and then propagated by the gap junction between the ICC networks and smooth muscle cells to make the peristalsis of gastrointestinal tract in autonomic rhythm. However, the mechanism of these ion channels in the pacemaker activity is still unclear, so we refer to make a review about the research progress on these pacemaker channels in this article to illuminate the mechanism of pacemaker activity in ICC.