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| 血管新生的分子机制与相关疾病 | |
| 引用本文： | 张梦泽,李国珅,赵欣童,铁璐.血管新生的分子机制与相关疾病[J].中国病理生理杂志,2016,32(9):1718. |
| 作者姓名： | 张梦泽 李国珅 赵欣童 铁璐 |
| 作者单位： | 1. 北京大学基础医学院药理学系, 北京 100191; 2. 北京大学第三医院, 北京 100191; 3. 北京积水潭医院, 北京 100035 |
| 基金项目： | 国家自然科学基金资助项目（No.81373405；No.30901803）；北京市支持中央高校共建项目--青年英才计划（No.YETP0053）；杨森科学研究委员会中国分会研究基金（No.JRCC2011药理01）；国家基础科学人才培养基金（No.J1030831/J0108）；北京市重点学科基础医学学科建设项目（No.BMU20110254） |
| 摘 要： | 正血管新生指从已存在的血管上生长出新的毛细血管的过程~(1])。该过程十分复杂,依赖血管内皮细胞、成纤维细胞、巨噬细胞和细胞外基质的相互作用,并受促血管新生分子和抗血管新生分子协同调控。生理条件下,促血管新生分子和抗血管新生分子保持动态平衡;一旦平衡被打破,机体就会出现多种疾病,如肿瘤、多种眼科疾病、帕金森病(Parkinson’s disease,PD)和阿尔茨海默症(Alzheimer’s di- |
| 关 键 词： | 血管新生 血管内皮生长因子 转化生长因子-β 纤维母细胞生长因子 肿瘤 |
| 收稿时间： | 2016-03-01 |
Angiogenesis: molecular mechanism and related diseases |
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| ZHANG Meng-ze,LI Guo-shen,ZHAO Xin-tong,TIE Lu.Angiogenesis: molecular mechanism and related diseases[J].Chinese Journal of Pathophysiology,2016,32(9):1718. | |
| Authors: | ZHANG Meng-ze LI Guo-shen ZHAO Xin-tong TIE Lu |
| Institution: | 1. Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China; 2. Third Hospital, Peking University, Beijing 100191, China; 3. Beijing Jishuitan Hospital, Beijing 100035, China |
| Abstract: | Angiogenesis is the process of capillary formation from the existing blood vessels, which is regulated by many cytokines. Balance of these cytokines plays an important role in angiogenesis. Unbalance of these cytokines, leading to excessive or insufficient blood vessel, relates to a variety of diseases, such as tumor, ophthalmic diseases and wound healing. Recently, it has been observed that angiogenesis is also involved in Parkinson's disease and Alzheimer's disease. This review mainly discusses the molecular mechanism of angiogenesis and related diseases, and emphasizes the value of targeting angiogenesis as a strategy to develop drugs for those diseases. |
| Keywords: | Angiogenesis Vascular endothelial growth factor Transforming growth factor-β Fibroblast growth factor Tumor |
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