| 大麻素受体二聚化及其激活机理 |
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| 引用本文： | 武楠,杨洋,安输,郭晓汐,徐天瑞,刘莹.大麻素受体二聚化及其激活机理[J].中国病理生理杂志,2016,32(1):172-178. |
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| 作者姓名： | 武楠 杨洋 安输 郭晓汐 徐天瑞 刘莹 |
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| 作者单位： | 昆明理工大学生命科学与技术学院信号传导实验室, 云南 昆明 650500 |
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| 基金项目： | 国家自然科学基金资助项目(No. 81473342; No.U130225);云南省人培基金(No. KKSY201326116);云南省高端科技人才基金(No. 2012HA008) |
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| 摘 要： |
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| 关 键 词： | 大麻素受体 二聚化 |
| 收稿时间： | 2015-08-17 |
Mechanism of dimerization and activation of CB1 and CB2 receptor |
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| WU Nan,YANG Yang,AN Shu,GUO Xiao-xi,XU Tian-rui,LIU Ying.Mechanism of dimerization and activation of CB1 and CB2 receptor[J].Chinese Journal of Pathophysiology,2016,32(1):172-178. |
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| Authors: | WU Nan YANG Yang AN Shu GUO Xiao-xi XU Tian-rui LIU Ying |
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| Institution: | Cell Signaling Laboratory, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China |
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| Abstract: | Cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2) are important members of G protein-coupled receptors (GPCRs). Numerous studies have shown that CB1 receptor can form heterodimers with dopamine receptors (D2), μ-opioid receptor (μOR), orexin-1 receptor, adenosine receptor (A2A) or β2 adrenergic receptors, and then forming an essential functional entity. This review summarizes the research progress on heterodimers of cannabinoid CB1 or CB2, the function of heterodimers as well as the downstream signalings. The different pharmacological properties of the receptor heterodimer lead to bringing a change in receptor pharmacology, which will have a profound impact on drug development. |
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| Keywords: | Cannabinoid receptor Dimerization |
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