膳食营养素摄入与前列腺癌

为探讨膳食营养素与前列腺癌的关系，对１０２例前列腺癌患者进行了１∶１配比的病例对照研究。根据近三月食物摄入量的平均值计算蛋白质、脂肪、糖类等１１种营养素及总执量的日平均摄入量，采用配对ｔ检验和条件Ｌｏｇｉｓｔｉｃ回归分析。结果表明：脂肪、糖类、视黄醇当量等的摄入量大能增加前列腺癌的危险性，维生素Ｃ、维生素Ｂ１等能降低其危险性，各营养素的多变量调整ＯＲ值及９５％可信区间分别为脂肪１．６５（１．３９～１．９６）、碳水化合物１．２２（１．１３～１．３１）、视黄醇当量３．１２（２．１８～４．７５）、维生素Ｃ０．６１（０．４６～０．８０）、维生素Ｂ１０．０２９（０．００９～０．０９）。本文还对各营养素增加或降低前列腺癌危险性的可能机制进行了讨论。

Relationship between Dietary Nutrients intakes and Human Prostate Cancer

In order to study the relationship between dietary nutrients intakes and prostate cancer, 1 : 1 matched case-control study was carried out with 102 patients suffered from histologically confirmed prostate cancer and 102 healthy controls. Total calories and 11 nutrients including protein, lipid and carbohydrates were calculated based on the mean food intakes in the latest 3 days. Analyzed by matched t-test and conditional logistic regression method, the results showed that high intakes of lipid, carbohydrates, and retinol increased the risk of prostate cancer, but vitamin C and vitamin B1 decreased the risk of prostate cancer. The multivariable adjusted ORs were 1.65 (95% confident interval (CI) 1.39-1.96) for lipid, 1.22 (95% CI 1.13-1.31) for carbohydrates, 3.21 (95% CI 2.18-4.75) for retinol, 0.61 (95% CI 0.6-0.80) for vitamin C, and 0.029 (95% CI 0.009-0.09) for vitamin B1. The authors discussed the possible mechanism of dietary nutrients contributing to the risk of prostate cancer.