单纯性肥胖青少年性发育的调查分析

用放免法测定肥胖组与对照组男女儿童血清睾酮、脱氢表雄酮硫酸酯（ＤＨＥＡＳ）的含量及性征与性成熟的状况。结果显示肥胖组男性儿童血清睾酮含量为（１０．３６±５．７２）ｎｍｏｌ／Ｌ，对照组为（８．６５±４．２１）ｎｍｏｌ／Ｌ，肥胖组显著地高于对照组（Ｐ＜０．０１）。肥胖组女性儿童血清ＤＨＥＡＳ含量为（８．２５±６．４７）ｐｍｏｌ／Ｌ，对照组为（５．６３±４．９８）ｐｍｏｌ／Ｌ，肥胖组亦明显高于对照组（Ｐ＜０．０１）。肥胖组男性睾丸的纵横径及阴茎的长度和围度与对照组比较均有显著性差异（Ｐ＜０．０１）。肥胖组男性首次遗精年龄及女性月经初潮年龄和第二性征发育均早于对照组，在统计学上均有显著意义（Ｐ＜０．０１）。提示肥胖组性激素分泌及性发育、性成熟均明显高于、早于对照组。由此可见肥胖促进了性发育和性成熟，使得肥胖儿易出现性早熟的倾向，因此对单纯性肥胖青少年的性教育显得更加重要。

The Influence of Obesity on Sexual Development in Pubertal Children

Serum testosterone and dehydroepiandrosterone sulfate (DHEAS) were measured in obesity and control groups using radioimmunoassay method (RIA). The sexual sign and sexual maturity were measured, too. The results showed that the contents of serum testosterone were 10.36 +/- 5.72 and (8.65 +/- 4.21) nmol/L in males of obesity and control groups respectively (P < 0.01). The levels of serum DHEAS were 8.25 +/- 6.47 and (5.63 +/- 4.98) pmol/L in femals of obesity and control groups, respectively. The length and beadth diameter of testis and length and surround of penis in males in obesity group were significantly higher than in control one (P < 0.01). The first spermatorrhea age of males in obesity group was significantly younger than that in control one (P < 0.01). Menarche age in females of obesity group and the second sexual sign development were earlier than that of control one (P < 0.01). It showed that sexual hormone, sexual development and sexual maturity were significantly higher and earlier in obesity group than those in control one.