早期原发性开角性青光眼的多焦视网膜电图变化

目的:观察早期原发性开角型青光眼多焦视网膜电图(mERG)一阶kernel反应(FOK)和二阶kerne反应(SOK)。方法:我们采用多焦视觉电生理检查系统(RETIscan3.15version)和Humphrey750视野计。检测了38只正常眼和早期开角型青光眼共42眼。记录了mERG的FOK和SOK的P1、N1波的振幅和峰时4个参数。将原始数据转入SPSS10.0软件进行统计学处理。结果:早期青光眼组,鼻上(SN)、鼻下(IN),颞下(IT),颞上(ST)4个象限以及总和反应FOK的P1波、N1波振幅P1波、N1波峰时与正常对照组无显著差异(P>0.05);青光眼组FOK正常的鼻颞侧差异消失。早期青光眼组SOK4象限以及总和反应的P1波振幅密度比正常对照组显著降低(P<0.05);N1波振幅密度轻度降低(P<0.05)。SOK的N1、P1波潜峰时在早期青光眼组与正常对照组间差异有显著性(P<0.05)。早期青光眼组的mERG检查结果与视野不一致。结论:mERG是一种检测青光眼的敏感方法,可以为早期青光眼的诊断提供有效的依据。

The m-ERG change in early-stage primary open-angle glaucoma

AIM: To assess the early-stage primary open-angle glaucoma (POAG) applying with the m-ERG first order kernel (FOK) and the second order kernel (SOK). METHODS: We used the multi-focal electrophysiological examination system (RETIscan 3.15 version) and the Humphrey 750 computer visual field analysis appliance. Examined 38 normal-subject-eyes and selected 42 eyes of early-stage primary open-angle glaucoma. Four parameters of P1 and N1 wave of the amplitude and latency of FOK and SOK were recorded. The SPSS10.0 software of statistics analyzed the primary data. RESULTS: In FOK, the amplitude of P1-wave and N1-wave, the latency of P1-wave and N1-wave in four quadrants were not significantly different between the early-stage glaucoma Groups and normal collative group (P>0.05), as well as in sum reaction (P>0.05); In the early-stage glaucoma groups,the normal difference between nasal and temporal was disappeared in FOK; The early-stage glaucoma groups,in SOK, the amplitude of P1-wave remarkably decreased (P<0.05), N1-wave slightly decreased (P<0.05), the latency of P1-wave and N1-wave remarkably prolonged (P< 0.05); In superior-nasal, interior-nasal, superior-temporal, interior-temporal quadrantal, as well as in sum reaction (P< 0.05). The results of m-ERG were not consistent with the visual field in the early-stage glaucoma groups. CONCLUSION: m-ERG is a sensitive method in examining glaucoma, and it can be used as an evidence in diagnosis of early-stage POAG.