Neuronal correlates of encoding and retrieval in episodic memory during a paired-word association learning task: a functional magnetic resonance imaging study |
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Authors: | F M Mottaghy N J Shah B J Krause D Schmidt U Halsband L Jäncke H-W Müller-Gärtner |
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Institution: | Department of Nuclear Medicine, Heinrich-Heine University Hospital, Moorenstra?e 5, D-40225 Düsseldorf, Germany, Tel.: +49-2461-61-6347, Fax: +49-2461-61-2820, DE Institute of Medicine (IME), Research Center Jülich, Jülich, Germany, DE Institute for Medical Psychology and Behavioral Neurobiology, Eberhard-Karls University, Tübingen, Germany, DE
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Abstract: | The investigation of memory function using functional magnetic resonance imaging (fMRI) is an expanding field of research.
The aim of this study was to demonstrate brain-activity patterns related to a word-pair association task employing a whole-brain
EPI sequence. Six right-handed, healthy male volunteers (mean age: 27.5 years) took part in the study. fMRI was performed
at a field strength of 1.5 Tesla with 26–32 slices parallel to the AC-PC line, depending on individual brain size. Distributed
brain regions were activated in episodic encoding and retrieval with similarities, but also (distinct) differences in activation
patterns. Bilateral prefrontal cortical areas were involved when comparing encoding as well as retrieval to the reference
condition (nonsense words). Furthermore, activation was observed in cerebellar areas during encoding, and activation in bilateral
parietal areas (precuneus and inferior parietal cortex) was differentially more pronounced during retrieval. The activation
of left dorsomedial thalamus during retrieval of high imagery-content word-pair associates may point to the role of this structure
in episodic retrieval. The direct cognitive subtraction of encoding minus retrieval yielded a differentially larger left prefrontal
activation. There was a differentially higher right prefrontal activation during retrieval than during encoding, underlining
the proposed right/left asymmetry for episodic memory processes.
Received: 10 June 1998 / Accepted: 23 April 1999 |
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Keywords: | Episodic memory Paired word association fMRI |
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