抗生殖免疫抗体及性激素与子宫内膜异位症发病的关系研究

目的 探讨患者抗生殖免疫抗体及性激素的变化与子宫内膜异位症(endometriosis,EMS)发病的关系.方法 回顾性分析268例EMS患者(其中年龄＞35岁组的EMS患者90例;年龄≤35岁组的EMS患者178例)和200例非子宫内膜异位症患者(其中年龄＞35岁组的非子宫内膜异位症患者72例,为同龄对照组;年龄≤35岁组的非子宫内膜异位症患者128例,为同龄对照组)的临床资料.用化学发光免疫分析法检测两组患者血清卵泡刺激素(follicle-stimulating homone,FSH)、黄体生成素(homone,LH)、睾酮(testosterone,T)、雌二醇(estradiol,E2)孕酮(progesterone,P)和泌乳素(prolactin,PRL)水平;采用酶联免疫法检测抗卵巢抗体(anti-ovarian antibodies,AOAb)、抗心磷脂抗体(anticardiolipin antibody,ACL)、抗子宫内膜抗体(anti-endometrial antibodies,EMAb)水平.结果 年龄＞35岁组和年龄≤35岁组EMS患者的P、PRL水平均高于同龄对照组,差异有统计学意义;年龄＞35岁组的EMS患者LH水平也显著高于同龄对照组,差异也有统计学意义(P＜0.05).其他激素各项指标比较,差异无统计学意义(P＞0.05).年龄＞35岁组和年龄≤35岁组EMS患者的抗生殖免疫抗体AOAb、ACL、EMAb阳性率明显高于同龄对照组,差异有统计学意义(P≤0.05).结论 ENS患者存在抗生殖免疫抗体变化,高孕激素、高泌乳素水平可能与EMS发病有关.

Association of anti-reproductive immunoassay antibodies and changes of gonadal steroids hormones in endometriosis

Objective To explore the association between anti-reproductive immunassay antibodies and changes of gonadal steroids hormones in endometriosis.Methods We retrospectively analyzed the clinical data of 268 patients with endometriosis（endometriosis group aged35 years old,90 cases;endometriosis group aged≤35 years old,178 cases）and 200 patients with non-endometriosis were retrospectively analyzed（patients control group aged35 years old,72 cases;patients control group aged≤35 years old,128 cases）.Chemiluminescence immunoassay was used to detect the levels of serum luteninizing,follicle stimulating homone（FSH）,homone（LH）,testosterone（T）,estradiol（E2）,progesterone（P）and prolactin（PRL）.The serum levels of anti-ovarian antibodies（AoAb）,anticardiolipin antibody（ACL）and anti-endometrial antibodies（EMAb） were detected by enzyme linked immunosorbent assay（ELISA）.Results The endometriosis group aged35 years old and aged≤35 years old showed higher serum P and PRL level,significantly higher reproductive autoantibody positive rate than control group endo aged35 years old and aged≤35 years old.The serum LH was significantly higher in endometriosis group B than that of control group aged35 years old（P0.05）.Comparison of the indicators of other hormones,there was no significant difference（P0.05）.Conclusion The result suggests that there exist anti-reproductive immunoassay autoantibodies changes in endometriosis patients.Higher P and higher PRL levels may play a role in the pathogenesis of endometriosis.