| BDNF基因多态性与男性青少年暴力攻击行为的关联性分析 |
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| 引用本文： | 邵阳,谢斌,汪栋祥,乔屹.BDNF基因多态性与男性青少年暴力攻击行为的关联性分析[J].神经疾病与精神卫生,2011,11(2):115-118. |
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| 作者姓名： | 邵阳 谢斌 汪栋祥 乔屹 |
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| 作者单位： | 上海交通大学医学院附属精神卫生中心,200030 |
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| 基金项目： | 科技部"十一五"支撑计划资助项目，上海市卫生局青年基金 |
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| 摘 要： | 目的 分析BDNF基因与青少年男性暴力行为之间的关系.方法 采用TaqMan探针SNP基因分型技术对139例男性暴力少教人员,98例非暴力男性少教人员以及259例正常成年男性进行BDNF基因(rs1103010,rs6265)位点的基因分型.分析攻击组和对照组的等位基因和基因型分布规律.结果 器力青少年男性rs1103010位点T等位基因频率高于正常对照组(31.7%vs 24.9%,P＜0.05),rs1103010与rs6265两位点构成的T-G单体型在暴力组中的频率也显著高于正常对照组(31.4%VS 23.4%.P＜0.05).结论 BDNF基因可能在青少年暴力行为的发生中起了作用.
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| 关 键 词： | 青少年 暴力 脑源性神经营养因子 单核甘酸多态性 |
Analysis of association between violent behavior and polymorphism of brain-derived neurotrophic factor (BDNF) gene in male adolescent |
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| Institution: | SHAO Yang ,XIE Bin , WANG Dong-xiang ,et al. (Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China) |
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| Abstract: | Objective To study the association of BDNF related gene polymorphisms with violent behavior in delinquent adolescents. Methods Two single nucleotide polyraorphisms （BDNF rsll03010 andrs6265） were detected using TaqMan SNP genotyping assay in 139 violence young male offenders, 98 non-violence young male offenders and 259 normal adult controls. The distribution of genotypic and allelic frequencies in the case and control groups was analyzed. Results The results showed that rsll03010 T allelic distribution and rsll03010--rs6265 T--G haplotype were associated with violence behavior （P〈 0. 05）. Conclusions The variance of BDNF gene polymorphism may play a role under violent behavior in male adolescents. |
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| Keywords: | Adolescence Violence BDNF Single nucleotlde polymorphism |
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