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| 妊娠相关蛋白A基因多态性与早发冠心病相关性研究 | |
| 引用本文： | 王加红,陈忠,马根山,张书富,马瑾,吴波. 妊娠相关蛋白A基因多态性与早发冠心病相关性研究[J]. 临床心血管病杂志, 2009, 25(6) |
| 作者姓名： | 王加红 陈忠 马根山 张书富 马瑾 吴波 |
| 作者单位： | 1. 上海市杨浦区中心医院心内二科,上海,200090 2. 东南大学附属中大医院心脏科 3. 上海杨浦区中心医院心内科 |
| 基金项目： | 南京市科技发展计划项目 |
| 摘 要： | 目的:探讨妊娠相关蛋白A(PAPP-A)第14外显子A/C(Tyr/Ser)基因多态性与我国早发冠心病的相关性.方法:早发冠心病(病例组)85例,非冠心病(对照组)93例,采用聚合酶链反应-限制性片段长度多态性方法(PCR-RFLP)分析PAPP-A基因多态性.结果:病例组PAPP-A基因型中CC型频率高于对照组,但2组总的基因型频率分布差异有统计学意义(χ2=10.302,P=0.016),A、C等位基因频率差异有统计学意义(P＜0.05).结论:PAPP-A第14外显子A/C(Tyr/Ser)基因多态性可能与我国早发冠心病的易感性有关. |
| 关 键 词： | 冠状动脉疾病,妊娠相关蛋白A 基因多态性 早发 |
Relationship between PAPP-A gene polymorphism and premature coronary heart disease |
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| WANG Jiahong,CHEN Zhong,MA Genshan,MA Jin,ZHANG Shufu,WU Bo. Relationship between PAPP-A gene polymorphism and premature coronary heart disease[J]. Journal of Clinical Cardiology, 2009, 25(6) | |
| Authors: | WANG Jiahong CHEN Zhong MA Genshan MA Jin ZHANG Shufu WU Bo |
| Affiliation: | 1Department of Cardiology;the Center of Yangpu Hospital;ShangHai;210009;China;2Department of Cardiology;Zhongda Hospital Affiliated Dongnan University;3Department of Cardiology;Center Hospital in Yangpu District of Shangnai |
| Abstract: | Objective:To investigate the relationship between pregnancy-associated plasma protein A(PAPP-A) gene polymorphism and premature coronary heart disease in Chinese.Method:Eighty-five patients of premature coronary heart disease(CHD) and ninety-three controls were enrolled and polymerase chain reaction-restriction fragement length polymorphism(PCR-RFLP) was used to analysis PAPP-A gene polymorphism.Result:Compared to controls,patients with premature CHD had higher frequencies of CC genotype.Then there were sig... |
| Keywords: | corornary disease pregnancy-associated plasma protein A gene polymorphism premature |
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