磁共振动态增强扫描成年山羊腰椎髓核：定量观察椎间盘的强化程度及

背景：营养物质的减少是诸多因素导致椎间盘退变的最终途径。许多研究表明椎间盘的营养主要通过终板途径，终板的退变与椎间盘退变也有着密切的关系。MRI动态增强扫描作为一种无创、简单、可重复的方法，逐渐被用于分析椎间盘的营养机制。 目的：观察成年山羊腰椎髓核的MRI动态增强扫描特点。 方法：选取健康成年山羊8只，体质量分别为38 kg及50 kg，共纳入32个腰椎髓核。行腰椎间盘常规矢状位T1-TSE-SPIR、T2WI-TSE-SPAIR和MRI动态增强扫描，观察髓核图像的信号特点，测量增强前及增强后0 min，5 min，10 min，30 min，1 h，1.5 h，2 h，2.5 h，3 h，3.5 h，4 h的髓核信号强度值，分析髓核时间-增强率曲线及峰值时间。 结果与结论：32个髓核在10 min内未见明显的强化，在30 min后开始上升，在3.5 h到达最高值，并处于平台期；4 h内未见明显的下降。提示正常成年山羊腰椎髓核的MRI动态增强扫描曲线具有一定的特征性，观察其MRI动态增强扫描曲线有利于进一步阐明髓核的营养机制。

Dynamic contrast-enhanced scanning of nucleus pulposus of adult goat: Quantitative observation of enhancement degree and nutrition state of intervertebral discs

BACKGROUND: The reduction of nutrient substances has been considered to be the main factor, which leads to the ultimate way to disc degeneration. Numerous studies have shown that nutrition of intervertebral disc is mainly obtained through endplate, and there is close relationship between the cataplasia of endplate and that of intervertebral disc. Dynamic contrast-enhanced MRI scans as a non-invasive, repeatable method that has been used to study nutrition mechanism disc. OBJECTIVE: To quantitatively analyze the characteristics of enhancement of nucleus pulpous of adult goat lumbar discs. METHODS: Eight 24-month-old goats, weighing 38 kg and 50 kg, were selected, a total of 32 lumbar inter-vertebral discs were included. After anesthesia for goats, we observed the signal changes of regions of interest by using T1-TSE-SPIR, T2WI-TSE-SPAIR and dynamic enhanced magnetic resonance scan. On the point of time before enhancement and 0 minute, 5 minutes, 10 minutes, 30 minutes, 1 hour, 1.5 hours, 2 hours, 2.5 hours, 3 hours, 3.5 hours and 4 hours after enhancement, the enhancement of nucleus pulposus was calculated and the time-enhancement ratio curve was used to analyze the perfusion characteristics. RESULTS AND CONCLUSION: The nucleus pulposus exhibited no obvious increase within 10 minutes and began to increase quickly at 30 minutes and achieved its peak enhancement at 3.5 hours, after which was the plateau stage. The time-enhancement ratio curve of nucleus pulposus is distinctive, which encourages more researches to explore the mechanism of nutrition.