| 烧伤后大鼠心肌组织唾液酸含量的变化 |
| |
| 引用本文： | 郇京宁,霍礼政,陈玉林,葛绳德.烧伤后大鼠心肌组织唾液酸含量的变化[J].中华整形外科杂志,1996(3). |
| |
| 作者姓名： | 郇京宁 霍礼政 陈玉林 葛绳德 |
| |
| 作者单位： | 第二军医大学长海医院烧伤研究所，解放军第二六四医院烧伤科 |
| |
| 摘 要： | 利用大鼠３０％Ⅲ度烧伤模型，探讨了烧伤大鼠心肌组织唾液酸含量的变化，同时还观察了心肌组织三磷酸腺苷酶（ＡＴＰａｓｅ）活性和Ｃａ（２＋）含量改变。结果表明：烧伤后大鼠心肌组织唾液酸显著降低，伤后３小时仅为对照组的５８．８％。同时心肌组织Ｎａ＋、Ｋ＋－ＡＴＰａｓｅ，Ｍｇ２＋－ＡＴＰａｓｅ和Ｃａ２＋－ＡＴＰａｓｅ活性降低，而Ｃａ２＋含量明显升高。提示：唾液酸含量与心肌膜结构和功能有密切关系。组织唾液酸含量的减少可能是造成烧伤后能量代谢紊乱，ＡＴＰａｓｅ功能降低以及钙超载的重要因素之一。
|
| 关 键 词： | 烧伤，唾液酸，三磷酸腺苷酶，心肌损害，钙离子 |
Effects of thermal injury on heart sialic acid content in rats |
| |
| Huan Jingning, Huo Lizheng, Chen Yulin,et al..Effects of thermal injury on heart sialic acid content in rats[J].Chinese Journal of Plastic Surgery,1996(3). |
| |
| Authors: | Huan Jingning Huo Lizheng Chen Yulin |
| |
| Abstract: | The myocardial sialic acid content, ATPase activities, and Ca2 level were investigated in rats with full thickness burn of 30% TBSA. The results showed that the burned rats had a decreased level of myocardial sialic acid which was only 58. 8% of controls at 3 h postburn. Myocardial Na ,K ATPase, Caz ,Mg2 -ATPase and Ca2 -ATPase activities were inhibited in burned rats. As compared to controls, the burned rats showed a higher level of Ca2 in heart tissue. This study indicated that there were abnormal energy metabolism, dysfunction of ion pump, and paradox Ca2 overload in burned rats,which may be associated with the decrease in sialic acid content in myocardium. |
| |
| Keywords: | |
| 本文献已被 CNKI 等数据库收录！ |
|
