A novel synthetic route to 11-deoxyanthracycline AB synthons |
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| Authors: | Hee-doo Kim Sang-ae Park Sang-sup Jew |
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| Affiliation: | 1. College of Pharmacy, Sookmyung Women's University, 53-12 Chungpa-dong 2-ka, Yongsanku, 140-742, Seoul, Korea
2. College of Pharmacy, Seoul National University, 139-742, Seoul, Korea
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| Abstract: | An efficient synthetic method for 11-deoxyanthracycline AB synthons is described. A versatile key intermediate vinyl bromide3 was prepared from 5-methoxy-1-tetralone in three steps, and then was converted to the allylic alcohols4 and8 which, in tum, fumished highly fuctionalized AB synthons7 and12, respectively, via sequential epoxidation-reduction-protection processes. |
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| Keywords: | 11-Deoxyanthracycline AB synthon Vinyl bromide Allylic alcohol Epoxidation 5-Methoxy-1-tetralone |
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