| 多巴胺诱导PC12细胞凋亡与多巴胺黑素生成的关系 |
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| 引用本文： | 唐小卿,冯鉴强,李平阳,郭瑞鲜,叶美红,陈培熹.多巴胺诱导PC12细胞凋亡与多巴胺黑素生成的关系[J].中国药理学通报,2004,20(3):269-272. |
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| 作者姓名： | 唐小卿 冯鉴强 李平阳 郭瑞鲜 叶美红 陈培熹 |
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| 作者单位： | 中山大学中山医学院生理学教研室,广州,518007 |
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| 摘 要： | 目的 探讨多巴胺黑素 (dopamine melanin ,DA M )的生成在多巴胺 (dopamine ,DA)诱导神经元凋亡中的意义。方法 以PC12细胞为多巴胺能神经元的细胞模型 ,采用透射电镜和流式细胞仪 (flowcytometry ,FCM )观察细胞凋亡 ,紫外 -可见光分光光度计检测DA M。结果 DA可诱导PC12细胞凋亡 ,DA M的生成与DA诱导的PC12细胞凋亡之间呈正相关关系。结论 DA M的生成量在DA诱导神经细胞凋亡具有重要作用
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| 关 键 词： | 多巴胺 PC12细胞 凋亡 多巴胺黑素 |
| 文章编号： | 1001-1978(2004)03-0269-04 |
| 修稿时间： | 2003年8月19日 |
Relationship between formation of DA-M and DA-induced apoptosis in PC12 cells |
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| TANG Xiao-Qing,FENG Jian-Qiang,LI Ping-Yang,GUO Rui-Xian,YE Mei-Hong,C HEN Pei-Xi.Relationship between formation of DA-M and DA-induced apoptosis in PC12 cells[J].Chinese Pharmacological Bulletin,2004,20(3):269-272. |
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| Authors: | TANG Xiao-Qing FENG Jian-Qiang LI Ping-Yang GUO Rui-Xian YE Mei-Hong C HEN Pei-Xi |
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| Abstract: | AIMTo study the significance of the formation of dopam ine-melanin (DA-M) in the apoptosis of PC12 cells induced by dopamine (DA). METHODSUsing PC12 cells as the model of dopaminergic neuron, DA-i nduced apoptosis in PC12 cells were observed by electron microscope and flow cyt ometry(FCM), and the formation of DA-M was detected by UV/VIS spectrometer. RESULTSDA induced PC12 cells apoptosis and there were positive corr elation between formation of DA-M and DA-induced apoptosis in PC12 cells. CONCLUSIONSThe formation of DA-M might play an important role in th e apoptosis induced by DA. |
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| Keywords: | dopamine PC12 cell apoptosis dopamine-melanin |
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