川椒丸对小鼠体内抑菌作用的实验研究

目的：观察川椒丸对小鼠体内肠道常见致病菌的影响，探讨其治疗湿热泄泻的作用机制。方法：分别腹腔注射小鼠致死量大肠杆菌、乙型副伤寒杆菌、痢疾杆菌3种不同的细菌菌悬液，制作腹泻感染动物模型，观察川椒丸高、中、低3个不同剂量（以下简称九香高、中、低剂量组）及肠康片、诺氟沙星胶袭对感染小鼠模型的存活率、存活动时间的影响。结果：与模型相比，各药物组均可显著提高3种不同细菌感染小鼠模型的存活率、明显延长其存活时间，差异具有统计学意义（P〈0．05），其中，诺氟沙星组、九香高制剂量组均明显优于肠康片组，差异具有统计学意义（P〈0．05），而九香中剂量组与肠康片组、九香高制剂量组与诺言氟沙星对感染模型小鼠存活率的提高及存活时间的延长相当。结论：川椒丸对腹腔注射致死量大肠杆菌、痢疾杆菌和乙型副伤寒杆菌等感染小鼠模型可明显提高其存活率，显著延长感染小鼠存活时间，并呈现一定的量效关系，表明其对感染模型小鼠具有较好的保护作用，对体内肠道常见致病菌具有较好抑制作用。

Experimental discussion on antibacterial role of Chuanjiao Wan on mice

Objective： To observe on effects of common pathogens of Chuanjiao Wan on mice, to explore mechanism of treating diarrhea. Methods： Production of diarrhea in animal models of infection, intraperitoneal injection E. coli, Bacillus paratyphi B, Shigella, observe effects of survival rate and activity time of mouse model of infection with 3 different doses Chuanjiao Wan plus Changkang tablets, capsules of norfloxacin （Short title Jiuxiang high, medium and low dose group）. Results： Comparsion mouse model, every dose group can increase survival rate and activity time, statistically significant difference （P〈0.05）, norfloxacin group and Jiuxiang high group are better than Changkang tablets group, statistically significant difference （P〈0.05）, norfloxacin group of activity time compare with Jiuxiang high group almost. Conclusion： Treating mouse model of intraperitoneal injection E. coli, Bacillus paratyphi B, Shigella with Chuanjiao Wan can increase survival rate and activity time, it show antibacterial role of Chuanjiao Wan on mouse model.