沐舒坦不同给药途径佐治小儿急性感染性喉炎的疗效观察

目的：探讨沐舒坦不同给药方式对小儿急性感染性喉炎治疗作用的差异性。方法：将140例婴幼儿急性感染性喉炎随机分成4组，每组35例。对照组（A组）给予抗感染、降温、镇静及氧气驱动雾化吸入布地奈德混悬液等治疗；沐舒坦雾化吸入组（B组）另给沐舒坦针剂雾化治疗，〈2岁者7．5mg／次，〉2岁者15mg／次，加生理盐水2ml，空气压缩泵雾化，每日2次，疗程5～7天；沐舒坦静脉滴注组（c组）另给沐舒坦针剂静滴治疗（用量同雾化，加入10％葡萄糖注射液20ml），每日2次，疗程5～7天；另给沐舒坦雾化联合静脉滴注组（D组）联合使用沐舒坦针剂静脉滴注及空气压缩泵雾化吸入每日2次，疗程5～7天，观察内容包括患儿呼吸困难、发热、声嘶、咳嗽、喉鸣音等症状及体征改善时间。结果：4种治疗方案中，联合组疗效最好，静滴组及雾化组疗效均优于对照组，患儿呼吸困难、发热、声嘶、咳嗽、喉呜音等症状及体征消失时间均明显缩短（P〈0．05）。结论：联合静脉滴注和雾化吸入沐舒坦治疗小儿感染性喉炎效果好。

Effective observation on treating acute infectious laryngitis by different routes of administration of ambroxol

Objective： To investigate the therapeutic effects of different administration ways on mucosolvan for acute infectious laryngitis. Methods： 140 children with acute i-nfectious laryngitis were divided randomly into 4 groups; there were 35 childen in each group. All groups were treated with anti-infection, cooling, conscious-sedation and nebulizating budesonide suspl with oxygn driving. The group treated with mucoso-lvan nebulization （the group B） were given 7.5mg/time-1 who yonger than 2 years and 15mg · time^-1 who older than 2 years mucosolvan by nebulization with 2ml normal sod-ium, once for 12 hours for 5-7 days additionally. The group treated with mucosolvan intravenous drip （the group C） were given the same dosage with the nebulization group of intravenous drip mucosolvan with 10% glucose solution, once for 12 hours for 5-7 days additionally. The group treated with mucosolvan nebulization and intravenous drip （the group D） were given the above dosage of intravenous drip mucosolvan and nebulization, once for 12 hours for 5-7 days. All the content observed included improved time of symptoms and physical signs such as dyspnea, fever, hoarseness, cough, laryngeal stridor. Results： Among the four treatment plans, the curative effect of the conjoined group was the best, that of the intravenous drip group and nebulization group were better than control group, disappearing time of symptoms and physical signs such as dyspnea, fever, hoarse-ness, cough, laryngeal stridor were shortened obviously. Conclusion： Treating acute infectious laryngitis by different routes of administration of ambroxol has a good effect.