冬凌草甲素经线粒体途径诱导肿瘤细胞凋亡的信号通路

 冬凌草甲素（oridonin，ORI）是从中草药冬凌草中提取出来的一种具有抗肿瘤活性的二萜类化合物。ORI作用于肿瘤细胞后，主要经线粒体途径诱导肿瘤细胞凋亡。信号转导通路在细胞增殖、分化和凋亡等生物过程发挥重要的作用。最近几年的研究发现，ORI可能通过四条信号转导通路参与启动线粒体凋亡途径。它们分别是p53通路、Ras／Raf／ERK通路、PI3K／Akt通路和NF-κB通路。深入研究ORI经线粒体途径诱导细胞凋亡的信号转导通路，对进一步阐明ORI在细胞内的作用靶点及其抗肿瘤的分子机制十分重要。

Oridonin triggering mitochondrial apoptotic pathway by the signal transduction pathways

Oridonin is a deterpenoid isolated from Rabdosia rubescences. It has excellent antitumor effect, whose mechanism is to induce apoptosis of tumor cells by mitochondrial pathway. Signal transduction pathway play an important part in cell proliferation,differentiation,apoptosis and so on. Recent studies suggested that Oridonin may trigger mitochondrial apoptosis pathway by four signal transduction pathways,which were p53, Ras/Raf/ERK, PI3K/Akt and NF-κB pathway. Further investigation on mitochondrial signal transduction pathway would be helpful to clarify the intracellular target and the antitumor molecular mechanism of ORI.