恶性小汗腺汗孔瘤一例

报告1例恶性小汗腺汗孔瘤。患者男，54岁。左胫前结节20余年，破溃3个月。皮肤组织病理检查：肿瘤位于表皮内，胞浆浅染的上皮细胞呈巢索状，细胞异型明显，核形不规则，分裂象多，可见派杰样细胞浸润。免疫组化染色示上皮膜蛋白(EMA)和角蛋白AE1/AE3阳性, 角蛋白7（CK7）阴性，PAS染色阴性。诊断：恶性小汗腺汗孔瘤。

A case of malignant eccrine poroma

A case of Malignant Eccrine Poroma is reported. A 54-year-old man presented with a nodule on the left leg for about 20 years,with superficial ulceration in the recent 3 months. Histopathology after excision of the lesion showed the tumor located in epidermis, epithelial cells with pale cytoplasm form nests and cords with obviously atypia such as irregularly-shaped nuclei, and numerous mitotic figures.Tumour cells involve the epidermis in a pagetoid fashion. Immunohistochemical analysis showed that the tumor cells stained positive with EMA and AE1/AE3,but not for CK7. And the PAS stain is negtive. These findings were consistent with Malignant Eccrine Poroma.