| 复方黄连胶囊对糖尿病大鼠血脂及血液流变学的影响 |
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| 引用本文： | 唐丽琴,刘圣,陈礼明,魏瑜.复方黄连胶囊对糖尿病大鼠血脂及血液流变学的影响[J].中国药房,2007,18(15):1129-1131. |
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| 作者姓名： | 唐丽琴 刘圣 陈礼明 魏瑜 |
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| 作者单位： | 安徽医科大学附属省立医院药剂科、国家中医药管理局药剂实验室,合肥市,230001 |
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| 摘 要： | 目的:研究复方黄连胶囊(CRCC)对糖尿病大鼠血脂及血液流变学的影响。方法:建立大鼠四氧嘧啶糖尿病模型,观察CRCC对其血脂及血液流变学指标的影响。结果:CRCC能降低总胆固醇、甘油三酯、低密度脂蛋白、极低密度脂蛋白、脂蛋白、全血黏度、全血还原黏度、聚集指数、刚性指数、血浆黏度、变形指数和纤维蛋白原含量,并能升高高密度脂蛋白。结论:CRCC能明显改善糖尿病大鼠的脂质代谢异常和血液流变学异常状态。
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| 关 键 词： | 糖尿病 复方黄连胶囊 脂质代谢 血液流变学 |
| 文章编号： | 1001-0408(2007)15-1129-03 |
| 收稿时间： | 10 30 2006 12:00AM |
| 修稿时间： | 12 31 2006 12:00AM |
Effects of Compound Rhizoma Coptidis Capsules on Hemorheology and Blood Lipid in Rats with Diabetes Mellitus |
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| TANG Liqin,LIU Sheng,CHEN Liming,WEI Yu.Effects of Compound Rhizoma Coptidis Capsules on Hemorheology and Blood Lipid in Rats with Diabetes Mellitus[J].China Pharmacy,2007,18(15):1129-1131. |
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| Authors: | TANG Liqin LIU Sheng CHEN Liming WEI Yu |
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| Institution: | Dept. of Pharmacy, The Affiliated Anhui Provincial Hospital, Anhui Medical University, Laboratory of Pharmacy, State Administration of Traditional Chinese Medicine, Hefei 230001, China |
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| Abstract: | OBJECTIVE: To study the effects of Compound Rhizoma Coptidis capsule (CRCC) on hemorheology and blood lipid in rats with diabetes mellitus(DM). METHODS: DM model was induced by alloxan. The effects of CRCC on hemorheology and blood lipid in DM rats were observed. RESULTS: The levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), very low density lipoprotein (VLDL), lipoprotein, the whole blood viscosity, the whole blood reductive viscosity, aggregation index (AI), rigidity index (IR), distortion deformation transformation index (TK) and fibrinogen (Fib) were all increased by CRCC, while the level of high density lipoprotein (HDL) was increased. CONCLUSION: CRCC can significantly improve the abnormalities in hemorheology and lipid metabolism in DM rats. |
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| Keywords: | Diabetes mellitus Compound Rhizoma Coptidis capsules (CRCC) Lipid metabolism Hemorheology |
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