前列腺素E1治疗犬油酸型急性肺损伤的实验观察

目的 观察前列腺素El联合呼气末正压(PEEP)对犬油酸型急性肺损伤(ALI)的治疗作用。方法 15只成年健康家犬随机分成3组，静脉注射油酸复制性肺损伤模型后分别给予PGEl雾化吸入或静脉滴注或雾化吸入生理盐水，同时联合PEEP治疗。结果PGEl治疗组犬动脉血氧分压(PaO2)、氧合指数(PaO2/FiO2)均明显改善，肺循环阻力(FVR)和平均肺动脉压(MRAP)均显著降低；且雾化吸入组动物体循环平稳，静脉治疗组体循环指标变化显著。结论 雾化吸入PGE1可选择性扩张肺血管．降低油酸型ALI犬MPAP和PVR．迅速提高PaO2／FiO2．且不影响体循环．

Effect of Prostaglandin E1 on Oleic Acid-induced Acute Lung Injury in Canine

Objective To observe the therapeutic effect of prostalandin E 1 (PGE 1) and post end-expiratory pressure (PEEP) on oleic-acid induced acute lung injury (ALI) in dogs.Methods 15 healthy adult mongrel dogs were randomized into 3 groups. After ALI models was successfully established by injecting oleic-acid through central vein hole of Swan-Ganz catheter, PGE 1 were nebulized or infused with PEEP.Results Pressure of artrial oxygen partial(PaO 2)and oxygenation index(PaO 2/FiO 2)were greatly improved, mean pulmonary arterial pressure (MPAP) and pulmonary vascular resistance(PVR) were greatly decreased during therapy. Systemic hemodynamics were stable during PGE 1 nebutization, but systemic hemodynamics greatly changed during PGE 1 infusion.Conclusion PGE 1 nebulization can selectively dilate pulmonary vascular, reduce MPAP and PVR of oleid-acid induced ALI dog models, and rapidly improve PaO 2 and PaO 2/FiO 2 without affecting systemic hemodyanmic.