Assessment of aortic wall stiffness in patients with Familial Mediterranean Fever |
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| Authors: | Tavil Yusuf Oztürk Mehmet Akif Ureten Kemal Sen Nihat Kaya Mehmet Güngör Cemri Mustafa Cengel Atiye |
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| Institution: | 1. Department of Cardiology, Gazi University School of Medicine, Be?evler 06500, Ankara, Turkey;2. Department of Rheumatology, Gazi University School of Medicine, Ankara, Turkey;3. Department of Rheumatology, Ministry of Healthy Etlik Education and Research Hospital, Ankara, Turkey;1. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Molecular Medicine Program, University of Utah Health Sciences Center and Intermountain Healthcare, Salt Lake City, UT;2. Department of Internal Medicine, Eccles Institute of Human Genetics, University of Utah Health Sciences Center and Intermountain Healthcare, Salt Lake City, UT;1. Department of Virology I, National Institute of Infectious Diseases, Tokyo, Japan;2. Department of Microbiology, School of Medicine, University of Yamanashi, Yamanashi, Japan;3. Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan;4. Department of Biosciences, Teikyo University of Science, Yamanashi, Japan;1. Division of Cancer Medicine, Department of Investigational Cancer Therapeutics, University of Texas M.D. Anderson Cancer Center, Houston, TX;2. Pinnacle Oncology Hematology, Scottsdale, AZ;3. Comprehensive Cancer Centers of Nevada and US Oncology, Las Vegas, NV;4. Hillman Cancer Center, Pittsburgh, PA;5. Amgen Inc, Thousand Oaks, CA;1. John A Moran Eye Center, University of Utah, Salt Lake City, Utah;2. Division of Epidemiology, University of Utah, Salt Lake City, Utah;3. Centre for Experimental Medicine, Queen''s University Belfast, Belfast, United Kingdom;1. Department of Perinatology, Zekai Tahir Burak Women’s Health Education and Research Hospital, Ankara, Turkey;2. Department of Cardiology, Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey;3. Department of Obstetrics and Gynecology, Konya Education and Research Hospital, Konya, Turkey;4. Department of Cardiology, Mersin State Hospital, Mersin, Turkey |
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| Abstract: | IntroductionTo evaluate aortic wall stiffness and its relation between the aortic stiffness and the left ventricular function in patients with Familial Mediterranean Fever (FMF).MethodsThe study population was composed of 31 patients with FMF in attack-free period (12 men, 19 women; mean age: 36 ± 7 years) and 27 healthy subjects (10 men, 17 women; mean age: 34 ± 7 years) who had volunteered to participate. Aortic stiffness indices, aortic strain and distensibility, were calculated from the aortic diameters measured by echocardiography and blood pressure obtained by sphygmomanometry.ResultsThere were significant differences between the control and the patient group in aortic strain (mean (SD), 7.23 ± 2.14 versus 4.91 ± 1.66%, p = 0.01) and distensibility (4.02 ± 1.42 versus 2.84 ± 1.46, 10?6 cm2 dyn?1, p = 0.001). Although there was no correlation between the aortic stiffness parameters and the left ventricular function parameters, there were significant negative correlations between the disease duration and aortic strain index (r = ?0.29, p < 0.001), and between the disease duration and distensibility (r = ?0.32, p < 0.001).ConclusionAortic stiffness measurements were found abnormal in patients with FMF. We have also demonstrated that there were significant correlations between aortic stiffness parameters and disease duration. |
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