| 抗癫痫药Rufina mide的合成 |
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| 引用本文： | 王俊敏 谢志峰 崔丽京 全哲山. 抗癫痫药Rufina mide的合成[J]. 延边医学院学报, 2004, 27(4): 264-266 |
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| 作者姓名： | 王俊敏 谢志峰 崔丽京 全哲山 |
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| 作者单位： | 延边大学药学院药物化学教研室，吉林延吉133000 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | [目的 ]研究抗癫痫新药Rufinamide的合成工艺 .[方法 ]合成方法是以 2 ,6 二氟苯甲酸为起始原料 ,经酯化、NaBH4还原及卤化得取代 2 ,6 二氟氯苄 ,再与迭氮钠反应得 2 ,6 二氟苄基迭氮 ,最后再与丙炔酸乙酯环合及酰氨化得Rufinamide.[结果 ]所合成的目标化合物经核磁共振氢谱、元素分析和质谱确认了化学结构 .
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| 关 键 词： | 癫痫 抗惊厥药 合成 |
| 文章编号： | 1000-1824(2004)04-0264-03 |
| 修稿时间： | 2004-10-12 |
Synthesis of the Rufinamide as antiepileptic medicine |
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| WANG Jun-min,XIE Zhi-feng,CUI Li-jing,QUAN Zhe-shan. Synthesis of the Rufinamide as antiepileptic medicine[J]. Journal of Medical Science Yanbian University, 2004, 27(4): 264-266 |
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| Authors: | WANG Jun-min XIE Zhi-feng CUI Li-jing QUAN Zhe-shan |
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| Affiliation: | WANG Jun-min,XIE Zhi-feng,CUI Li-jing,QUAN Zhe-shan* |
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| Abstract: | OBJECTIVE?To study the synthesis process of the Rufinamide as a new antiepileptic medicine.?METHODS?By us ing 2,6-difluorobenzoic acid as the starting material, 2,6-difluorobenzyl chlo ride was prepared via esterification, NaBH 4 reduction and halogenation, which subsequently reacted with sodium azide to give 2,6-difluorobenzyl azide, th en t he Rufinamide was obtained via cyclizing with ethyl propiolate and amidating.? RESULTS?The structure of the synthesized compound is determined by 1 H-NMR, IR and MS. |
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| Keywords: | epilepsy anticonvulsants synthesis |
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