| 加替沙星葡萄糖注射液中葡萄糖降解产物的检查 |
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| 引用本文： | 王亚静. 加替沙星葡萄糖注射液中葡萄糖降解产物的检查[J]. 华西药学杂志, 2006, 21(2): 204-205 |
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| 作者姓名： | 王亚静 |
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| 作者单位： | 天津药物研究院制剂中心,天津,300193 |
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| 摘 要： | 目的探讨适合输液中葡萄糖降解产物的检查方法。方法利用主药与葡萄糖降解产物间的性质差异,选择离子交换树脂对主药进行选择性吸附,排除主药对检测的干扰,再用常规方法检查葡萄糖的降解产物。结果可较好地控制加替沙星葡萄糖注射液的质量。结论所建方法准确可行,适合于加替沙星品种中葡萄糖降解产物的检查,较直接测定5-羟甲基糠醛更有指导意义。
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| 关 键 词： | 加替沙星 葡萄糖注射液 降解产物 5-羟甲基糠醛 |
| 文章编号： | 1006-0103(2006)02-0204-02 |
| 收稿时间： | 2005-10-01 |
| 修稿时间： | 2005-10-01 |
Examination of glucose degradation substance in Gatifloxacin glucose injection |
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| WANG Ya-jing. Examination of glucose degradation substance in Gatifloxacin glucose injection[J]. West China Journal of Pharmaceutical Sciences, 2006, 21(2): 204-205 |
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| Authors: | WANG Ya-jing |
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| Affiliation: | Pharmaceutical Center, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China |
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| Abstract: | OBJECTIVE To study suitable glucose degradation substance examination method of Gatifloxacin glucose injection.METHODS According to the different physical character between remedy and glucose degradation substance,a suitable ion-exchange resin was chosen in order to eliminate remedy selectively.RESULTS It was proved that the glucose degradation substance examination method was successful in quality control of Gatifloxacin glucose injection.CONCLUSION The method is accurate,applicable,and it is suitable for analogues examination of glucose degradation substance.It is better than controlling 5-hydroxymethylfurfural only. |
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| Keywords: | Gatifloxacin Glucose injection Degradation substance 5-Hydroxymethylfurfural |
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