45株副流感嗜血杆菌感染及耐药性调查

目的了解本地区呼吸道感染中副流感嗜血杆菌的感染情况及耐药性,以便有效地指导临床合理用药。方法对760例呼吸道感染患者的呼吸道分泌物进行副流感嗜血杆菌的培养及鉴定,以K-B法进行药物敏感性试验。β-内酰胺酶试验采用Nitrocefin纸片法。结果共分离出副流感嗜血杆菌45株,分离率为5.92%(45/760)。药敏结果显示阿莫西林/克拉维酸、阿奇霉素、亚胺培南、头孢他啶、头孢呋辛的耐药性较低,均小于5%,是治疗的首选药物。β-内酰胺酶阳性率为37.78%(17/45)。结论本地区呼吸道感染副流感嗜血杆菌耐药形势严峻,β-内酰胺酶阳性率较高,应引起重视。

Study on the drug resistance of 45 hacemophilus par lainfluenzae in respiratory tract infection

Objective To investigate the infectious state and drug resistance of Haemophilus par lainfluenzae in respiratory tract infection, so as to instruct the rational use of antibiotics. Methods Haemophilus par lainfluenzae were isolated from the pa-tients with respiratory tract infection and performed by K-B methods. Nitrocefin slip test was applied into detecting β-lactamase. Re-sults A total of 45 Hacmophilus par lainfluenzae were isolated from 760 specimen, with the isolation rate being 5.92%. Amoxicil-lin/claulanic acid,Azithromycin, Imipenem,Ceftazidime and Cefuroxime had the better antibiotic function and the average drug re-sistance was lower than 5 % ,The β-lactamase positive rate was 37.78 %. Conclusion The high drug resistance and β-lactamase pos-itive rate of Haemophilus par lainfluenzae isolated from respiratory tract characterized by multi-resistance must be taken seriousely.