胰岛素泵在2型糖尿病并肺部感染的应用效果观察

目的观察应用胰岛素泵进行连续皮下胰岛素输注(CSII)治疗2型糖尿病并肺部感染患者强化血糖控制的疗效。方法将住院的2型糖尿病并肺部感染患者83例随机分为皮下胰岛素泵治疗组(CSII组,42例)和多次皮下注射治疗组(MSII组,41例),观察血糖、血糖下降至正常的时间、肺部感染控制时间、费用及低血糖发生率。结果两组患者的血糖治疗后均明显下降,达目标血糖值的时间、肺部感染控制时间、胰岛素用量、低血糖发生率CSII组较MSII组明显减少(P<0.05);CSII组治疗后糖化血红蛋白、总胆固醇、C-反应蛋白明显降低,而空腹C肽、高密度脂蛋白-胆固醇明显升高(P<0.05)。而MSII组治疗前后上述指标的差异无统计学意义(P>0.05)。结论CSII能更好地控制血糖,纠正代谢紊乱,减少费用和住院天数,并能减少低血糖发生,是较为理想的方法。

Effect of insulin pump in treatment of type two diabetic patients with pulmonary infections

Objective To study the effect of continuous subcutaneous insulin injection(CSII) in treatment of type two diabetic patients with pulmonary infections. Methods From January 2001 to December 2005,83 type two diabetic patients with pulmonary infections were randomized to group CSII (42 cases) and group MSII(41 cases). The period of normalization of the blood glucose and cure of the pulmonary infections, cost and morbidity of low blood glucose were observed. Results Blood glucose of all patients in two groups reduced significantly. Significant difference was observed in the period of cure of the pulmonary infections, usage amount of insulin and morbidity of low blood glucose. In group CSII HbA1c, CRP and CHOL reduced significantly. Fasting CRP and high density lipoprotein-C (HDL-C) were remarkably increased. Conclusions Consecutive subcutaneous insulin pump injection is able to control the blood glucose better, to correct metabolic disorder, reduce the cost and hospital day and decrease the morbidity of low blood glucose. CSII is a better of method.