三七杜仲颗粒对去势雌性大鼠骨密度的影响 |
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引用本文: | 阳春华,;胡余明,;李梓民. 三七杜仲颗粒对去势雌性大鼠骨密度的影响[J]. 实用预防医学, 2014, 0(7): 874-876 |
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作者姓名: | 阳春华, 胡余明, 李梓民 |
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作者单位: | [1] 长沙市第一医院骨科,湖南长沙410005; [2] 湖南省疾病预防控制中心毒理科,湖南长沙410005; |
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摘 要: | 目的探讨三七杜仲颗粒对去势大鼠骨密度的作用。方法 SPF级雌性SD大鼠60只,随机分成6组:三七杜仲颗粒低、中、高剂量组(0.167、0.333、1.000 g/kg·bw),碳酸钙对照组、模型对照组及假手术组。12周后,测定动物体重、股骨干重、骨密度和骨钙含量。结果高剂量组股骨中心骨密度、股骨远心端骨密度、骨钙含量显著高于模型对照组(P0.05)。结论三七杜仲颗粒具有增加去势大鼠骨密度的功能。
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关 键 词: | 三七杜仲颗粒 骨密度 骨质疏松症 去势大鼠 |
Effect of Sanqi Granule on bone mineral density in ovariectomized rats |
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Affiliation: | YANG Chun - hua , HU Yu - ming, LI Zi - min (Department of Orthopaedics, the First Hospital of Changsha City, Changsha, Hunan 410005, China) |
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Abstract: | Objective To explore the role of Sanqi Duzhong Granule in increasing bone mineral densities of ovariectomized rats. Methods Sixty female Sprague Dawley rats were divided into 6 groups, including low , medium - and high- dose Sanqi Duzhong Granule groups (0. 167, 0. 333 and 1. 000 g/kg. bw), calcium carbonate control group, model control group and sham operation group. All rats in the 6 groups were respectively treated with their test materials for 12 weeks. Then body weight, thighbone weight, bone densities and calcium quantities of bone of all the rats were measured. Results Body mineral densities of the midpoint and the distal femur as well as the calcium content of the femur were significantly higher in high- dose group than in model control group (P 〈 0.05). Conclusions Sanqi Duzhong Granule can increase the bone mineral densities of rats. |
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Keywords: | Sanqi Duzhong Granule Bone mineral density Osteoporosis Ovariectomized rat |
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