Anti-inflammatory phenylpropanoid glycosides from <Emphasis Type="Italic">Clerodendron trichotomum</Emphasis> leaves |
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Authors: | Kyoung Hee Kim Sungun Kim Min Young Jung In Hye Ham Wan Kyunn Whang |
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Institution: | (1) College of Oriental Medicine, Kyung-hee University, Seoul, 130-701, Korea;(2) College of Pharmacy, Chung-Ang University, Seoul, 156-756, Korea;(3) College of Pharmacy, Chung-Ang University, 221 Huekseok-Dong Dongjak-gu, Seoul, 156-756, Korea |
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Abstract: | The chromatographic separation of MeOH extract from Clerodendron trichotomum Thunberg leaves led to the isolation of three phenylpropanoid compounds. Using spectroscopic methods, the structures of these
compounds were determined as β-(3′, 4′-dihydroxyphenyl)ethyl-O-α-L-rhamnopyranosyl (1→3)-β-D-(4-O-caffeoyl)-glucopyranoside, acteoside (verbascoside) (1), β-(3′, 4′-dihydroxyphenyl)ethyl-O-α-L-rhamnopyranosyl (1→3)-β-D-(6-O-caffeoyl)-glucopyranoside, isoacteoside (2), β-(3′, 4′-dihydroxyphenyl) ethyl-O-α-L-rhamnopyranosyl (1→3)-β-D-glucopyranoside, and decaffeoylacteoside (3). We measured the anti-inflammatory activity of these three phenylpropanoid compounds both in vitro (DPPH Reduction Assay, TBARS Assay on Cu 2+-induced oxidized LDL, PGE2 assay) and in vivo (acetic acidinduced vascular permeability in mice and carrageenan-induced hind paw edema in rats). 80% methanol fraction
and acteoside had the activity. |
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Keywords: | Clerodendron trichotomum Verbenaceae Acteoside Verbascoside Isoacteoside Decaffeoylacteoside Anti-inflammatory activity |
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