反义技术治疗肿瘤的临床进展

反义技术是根据核酸间的碱基互补原理 ,用生物合成或人工合成的互补反义核酸或其化学修饰物与细胞内的特定核酸结合以抑制或封闭其表达。在肿瘤治疗方面 ,人们以癌变过程中的不同突变基因为靶位 ,设计了许多反义抗肿瘤药物 ,其中部分已进入临床试验阶段。作者对已进入临床试验阶段的反义抗肿瘤药物进行综述

The clinical progress of antisense technology in the treatment of cancer

According to the base complementation, the principle antisense technology is the sequence specific binding of complementary antisense nucleic acids or their chemical modification to the nucleic acids in cells, resulting in the suppression or prevention of gene translation. For the treatment of cancer, a lot of antisense drugs have been designed, which target the genes involved in the pathogenesis of cancer. And some of them have been in clinical trials. The author reviewed the progress of the clinical trials of these antisense drugs.