Fatty acid profiles,antioxidant
status,and growth of preterm infants fed diets without or with
long-chain polyunsaturated fatty acids |
| |
Authors: | Email author" target="_blank">Berthold?KoletzkoEmail author Ulrike?Sauerwald Ursula?Keicher Helmut?Saule? Susanne?Wawatschek Hansjosef?B?hles Karin?Bervoets Mathilde?Fleith Gayle?Crozier-Willi |
| |
Institution: | (1) Dr. von Hauner Children s Hospital, Ludwig-Maximilians-University of Munich, Lindwurmstr. 4, 80337 München, Germany;(2) Kinderabteilung, Zentralklinikum Augsburg, Augsburg, Germany;(3) Zentrum der Kinderheilkunde, University of Frankfurt/Main, Frankfurt/M., Germany;(4) Nestec Ltd., Nestle Research Center, Lausanne, Switzerland |
| |
Abstract: | Summary.
Long-chain polyunsaturated fatty acids (LCP) are
considered conditionally essential nutrients for the infant born
prematurely, and attempts are being made to match fatty acid
profiles of formula and breast fed infants. In this
double-blind, randomized study we investigated the effects of a
formula enriched with both n-6 and n-3 LCP on plasma fatty acid
profiles, antioxidant status and growth of premature infants. 29
infants received either a formula devoid of LCP or a LCP
supplemented formula (0.5 g/100 g fat linoleic acid metabolites,
0.8 g/100 g fat -linolenic acid metabolites). 17 breast fed
infants served as a control group. At study entry as well as two
and four weeks later, plasma and urine samples were collected,
growth data obtained and food tolerance was documented. At the
end of the four week study period, plasma docosahexaenoic acid
(DHA) levels of supplemented infants were significantly higher
than those of unsupplemented infants and similar to those of
infants fed human milk. Plasma n-6 LCP concentrations including
arachidonic acid (AA) were similar between groups. The plasma
-tocopherol levels of breast fed and supplemented infants were
similar and tended to be lower than in infants fed the formula
devoid of LCP. Urinary malondialdehyde (MDA) excretion of
formula fed infants was significantly higher compared to infants
fed human milk, but did not differ between the two formula
groups. Parameters of growth and milk tolerance did not differ
between groups. Our results demonstrate that plasma LCP levels
similar to those of breast fed infants can be achieved with the
LCP supplemented formula used in this trial, without evidence of
adverse effects of the LCP enrichment.AA
arachidonic acid
- ALA
-linolenic acid
- DGLA
dihomo- -linolenic acid
- DHA
docosahexaenoic acid
- EPA
eicosapentaenoic acid
- F
formula devoid of LCP
- GLA
-linolenic acid
- HM
human milk
- LA
linoleic acid
- LCP
long-chain polyunsaturated fatty acids
- LCP-F
formula enriched with LCP
- MDA
malondialdehyde
- PC
phosphatidylcholine
- PCA
postconceptional age
- PE
phosphatidylethanolamine
- PUFA
polyunsaturated fatty acid |
| |
Keywords: | docosahexaenoic acid omega 3 fatty acids lipid peroxidation vitamin E low birthweight infant nutrition |
本文献已被 PubMed SpringerLink 等数据库收录! |
|