Persistent Colonization of Nine Cystic Fibrosis Patients with an<Emphasis Type="Italic"> Achromobacter</Emphasis> (<Emphasis Type="Italic">Alcaligenes</Emphasis>)<Emphasis Type="Italic"> xylosoxidans</Emphasis> Clone |
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Authors: | M?Kanellopoulou Email author" target="_blank">S?PournarasEmail author H?Iglezos N?Skarmoutsou E?Papafrangas A?N?Maniatis |
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Institution: | (1) Department of Microbiology, Sismanoglion General Hospital, Athens, Greece;(2) Department of Microbiology, Medical School, University Hospital of Larissa, 411 10 Mezourlo, Larissa, Greece |
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Abstract: | The present study was conducted to investigate the increasing incidence of Achromobacter (previously Alcaligenes) xylosoxidans isolates being recovered from sputum samples of cystic fibrosis patients at a cystic fibrosis department for adults in Athens, Greece. During the 1-year study period, a total of 34 isolates were detected persistently in 9 of 71 cystic fibrosis patients. The isolates exhibited resistance to multiple antimicrobial agents. Isolates that were recovered repeatedly from each patient exhibited identical macrorestriction profiles with pulsed-field gel electrophoresis, indicating that the same strain persisted in the lungs of these patients. Isolates from five of the patients were genetically related, suggesting a common-source outbreak of Achromobacter xylosoxidans colonization or infection. |
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