| 心房肽对高血压模型鼠(SHR)免疫细胞内钙调蛋白含量的影响 |
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| 引用本文： | 夏邦顺,杨贵贞.心房肽对高血压模型鼠(SHR)免疫细胞内钙调蛋白含量的影响[J].现代免疫学,1990(4). |
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| 作者姓名： | 夏邦顺 杨贵贞 |
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| 作者单位： | 白求恩医科大学免疫学教研室，白求恩医科大学免疫学教研室 长春 130021，长春 130021 |
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| 摘 要： | 本文探讨了心房肽对自发性高血压大鼠免疫细胞内钙调蛋白含量的影响,结果表明,心房肽可单独或协同ConA增加大鼠胸腺细胞内活化钙调蛋白的含量;但心房肽单独却不足以影响大鼠脾细胞内活化钙调蛋白的含量,只能协同ConA促进大鼠脾细胞内活化钙调蛋白水平的增加。同时发现,自发性高血压大鼠免疫细胞在心房肽的直接或协同丝裂原作用下所增加的钙调蛋白含量低于正常血压对照鼠。
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EFFECT OF ATRIAL NATRIURETIC POLYPEPTIDES ONINTRACELLULAR CALMODULIN OF IMMUNE CELLSOF SPONTANEOUSLY HYPERTENSIVE RATS |
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| Abstract: | The effect of atrial natriuretic polypeptides on the intracellular calmodulin of immune cells of spontaneously hypertensive rats (SHR) was investigated. It was found that the polypeptides could work both independently and synergistically with Con A to increase the content of intracellular calmodulin in rat thymocytes but only synergistically in rat splenocytes. It was also found that the amount increased in SHR was lower than that in WKA rats. |
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