| MTHFR A1298C基因多态性与高尿酸血症的相关性探讨 |
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| 引用本文： | 邱承真,彭景. MTHFR A1298C基因多态性与高尿酸血症的相关性探讨[J]. 现代医院, 2011, 11(11): 18-20. DOI: 10.3969/j.issn.1671-332X.2011.11.008 |
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| 作者姓名： | 邱承真 彭景 |
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| 作者单位： | 扬州大学旅游烹饪学院,江苏扬州,225127 |
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| 摘 要： | 目的探讨亚甲基四氢叶酸还原酶(MTHFR)基因A1298C单核苷酸多态性与高尿酸血症(HUA)的关系。方法以聚合酶链反应和限制性片段长度多态性方法对116例高尿酸血症患者和110例正常对照组MTHFR A1298C基因型作比较。结果在高尿酸血症病人中MTHFR 1298AA、AC、CC基因型频率分别为73.3%、23.3%和3.4%,而在正常对照组中分别为70.0%、26.4%和3.6%,两者无显著差异。结论 MTHFR A1298C单核苷酸多态可能与高尿酸血症的遗传易感性无关。
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| 关 键 词： | MTHFR A1298C 高尿酸血症 多态性 |
STUDY ON RELATIONSHIP BETWEEN GENETIC POLYMORPHISMS IN METHYLENETETRAHYDROFOLATE REDUCTASE AND HYPERURICEMIA |
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| QIU Chengzhen,PENG Jing. STUDY ON RELATIONSHIP BETWEEN GENETIC POLYMORPHISMS IN METHYLENETETRAHYDROFOLATE REDUCTASE AND HYPERURICEMIA[J]. Modern Hospital, 2011, 11(11): 18-20. DOI: 10.3969/j.issn.1671-332X.2011.11.008 |
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| Authors: | QIU Chengzhen PENG Jing |
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| Affiliation: | QIU Chengzhen,PENG Jing Tourism and Cuisine College of Yangzhou University,Yangzhou City,Jiangsu Province 225127 PRC |
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| Abstract: | Objective To determine whether the genetic polymorphism in methylene-tetrahydrofolate reductase(MTHFR A1298C) are associated with the risk of hyperuricemia(HUA). Methods A hospital-based,case-control study consisting of 116 cases of HUA and 110 controls matched on age,sex was conducted to investigate the association between the polymorphism in MTHFR and susceptibility to HUA.Genotypes of MTHFR A1298C were analyzed by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) methods. Resul... |
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| Keywords: | MTHFR A1298C Hyperuricemia(HUA) Genetic polymorphism |
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