Nasopharyngeal carriage of Haemophilus influenzae |
| |
| Authors: | Das B K Arora N K Mathur P Ostwal P Mandal S Kabra S K Kapil A Lalitha M K Thomas K |
| |
| Affiliation: | Department of Microbiology, All India Institute of Medical Sciences, New Delhi. Bimal@aiims.aiims.ac.in |
| |
| Abstract: | OBJECTIVE: Nasopharyngeal colonization of Haemophilus influenzae (H. influenzae) in young children may be important in developing countries. METHOD: In this study, we screened school going children for carriage of H. influenzae. A total of 44 H. influenzae isolates out of a collection of 162 were characterized for biotypes, capsular serotypes and antibiotic resistance. RESULTS: A significant proportion of H. influenzae (25/44) isolates were serotype b. High antibiotic resistance was observed against commonly administered antibiotics like ampicillin (79%), chloramphenicol (20%), trimethoprim sulfamethoxazole (84%) and erythromycin (95%). Comparison of antibiotic resistance profile of nasopharyngeal isolates was observed to be correlated with those of H. influenzae from disease. CONCLUSION: Multidrug resistant nasopharyngeal H. influenzae in young healthy children may act as reservoir. Monitoring of antibiotic resistance among nasopharyngeal H. influenzae as a surrogate for invasive H. influenzae seems an attractive option. |
| |
| Keywords: | Haemophilus influenzae Nasopharyngeal carriage Colonization Multidrug resistant |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
