| CDH1基因多态性与胃腺癌患者舌苔辨证的相关性 |
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| 引用本文： | 秦蕾,张军峰,杨亚平,李谨,佟书娟,张春兵,赵旺胜,杨学文,邱红,董伟,詹瑧. CDH1基因多态性与胃腺癌患者舌苔辨证的相关性[J]. 世界华人消化杂志, 2012, 0(14): 1191-1198 |
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| 作者姓名： | 秦蕾 张军峰 杨亚平 李谨 佟书娟 张春兵 赵旺胜 杨学文 邱红 董伟 詹瑧 |
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| 作者单位： | 南京中医药大学中西医结合学科;南京医科大学口腔医学研究所;江苏省中医院;江苏省人民医院;中国人民解放军第八一医院 |
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| 基金项目： | 国家自然科学基金资助项目,No.30973715;No.81001502;江苏省自然科学基金资助项目,No.BK2008461;江苏高校优势学科建设工程基金资助项目(PAPD)~~ |
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| 摘 要： | 目的:研究CDH1基因多态性与胃腺癌患者舌苔辨证的关系.方法:应用连接酶检测反应,对387例胃腺癌患者和392例健康对照的CDH1基因的4个位点进行基因分型,并且按中医舌诊辨证要求,由中医诊断学专家进行舌色、舌质的诊断.结果:胃腺癌组不按时吃饭的比例高于对照组(2=9.124,P=0.010),胃腺癌组与对照组相比饮食口味偏咸(2=74.409,P<0.001),胃腺癌组的吸烟率高于对照组(2=18.019,P<0.001),胃腺癌组经常吃豆制品的频率明显低于对照组(2=10.669,P=0.014),并且其经常吃新鲜水果的频率明显低于对照组(2=59.905,P<0.001).rs13689、rs17690554位点携带突变基因型并且苔色为黄色的个体在病例组的分布频率明显高于对照组(2=4.064,P=0.044;2=5.868,P=0.015).两组人群在各位点同一基因型的不同苔质的差异均具有统计学意义(P<0.050).结论:CDH1基因多态性与胃腺癌患者舌苔辨证有一定关联,本研究结果有助于揭示胃腺癌患者基因位点突变与舌苔形成和变化的科学内涵.
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| 关 键 词： | 胃腺癌 CDH1基因 基因多态性 舌苔 |
Association between CDH1 gene polymorphisms and tongue coatings in patients with gastric adenocarcinoma |
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| Lei Qin,Jun-Feng Zhan. Association between CDH1 gene polymorphisms and tongue coatings in patients with gastric adenocarcinoma[J]. World Chinese Journal of Digestology, 2012, 0(14): 1191-1198 |
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| Authors: | Lei Qin Jun-Feng Zhan |
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| Affiliation: | g,Ya-Ping Yang,Shu-Juan Tong,Wei Dong,Zhen Zhan,Department of Integrated Chinese and Western Medicine,Nanjing University of Traditional Chinese Medicine,Nanjing 210046,Jiangsu Province,China Jin Li,School of Stomatology,Nanjing Medical University,Nanjing 210029,Jiangsu Province,China Chun-Bing Zhang,Xue-Wen Yang,Jiangsu Provincial Hospital of TCM,Nanjing 210029,Jiangsu Province,China Wang-Sheng Zhao,People’s Hospital of Jiangsu,Nanjing 210029,Jiangsu Province,China Hong Qiu,the 81st Hospital of Chinese PLA,Nanjing 210002,Jiangsu Province,China |
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| Abstract: | AIM:To investigate the association between CDH1 gene polymorphisms and tongue coatings in patients with gastric adenocarcinoma.METHODS:PCR-RFLP method was used to detect the polymorphisms of the CDH1 gene in 387 patients with gastric adenocarcinoma and 392 normal control subjects.RESULTS:The percentages of subjects not eating on time,those eating salty flavor,and smoking subjects were higher in the gastric adenocarcinoma group than in the control group (2=9.124,P=0.010;2=74.409,P < 0.001;2=18.019,P < 0.001).The frequencies of regularly eating soy products and fresh fruit in the gastric adenocarcinoma group were significantly lower than those in the control group (2=10.669,P=0.014;2=59.905,P < 0.001).The frequencies of mutated genotypes of rs13689 and rs17690554 and yellow tongue coating were significantly higher in the case group than in the control group (2=4.064,P=0.044;2=5.868,P=0.015).CONCLUSION:CDH1 gene polymorphisms may be associated with the change in tongue coatings in patients with gastric adenocarcinoma. |
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| Keywords: | Gastric adenocarcinoma CDH1 gene Gene polymorphism Tongue coatings |
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