石墨炉原子吸收分光光度法测定胶囊剂囊壳及明胶空心胶囊中总铬含量

目的:采用石墨炉原子吸收分光光度法测定胶囊剂的囊壳及明胶空心胶囊中总铬含量。方法:采用不同条件的微波消解对胶囊剂及明胶空心胶囊壳进行前处理,在波长357.9 nm下,通过石墨炉程序升温进行测定。结果:方法线性良好;不同条件的微波消解,方法回收率均可达82%～94%。采用该方法对97批胶囊剂、52批明胶空心胶囊、6批明胶进行了总铬含量测定。结论:该方法适应性宽,可用于胶囊剂囊壳、明胶空心胶囊、明胶中总铬含量的测定。2种消解方法的测定结果基本一致。

Determination of total chromium content in vacant capsules and capsule shells by graphite furnace atomic absorption

Objective:To determine chromium content in capsules and capsule shells by graphite furnace atomic absorption.Methods:Microwave digestion was adopted for pretreatment of the vacant capsules and capsule shells.Graphite furnace temperature control program was optimized.The slit width was 0.4 nm,and the content of chromium was determined at the wavelength of 357.9 nm.Results: The linear of the method was good;the recovery of different microwave digestion conditions obtained in the accuracy test was in the range of 82%-94%.The contents of chromium in 97 lots capsules,52 lots gelatin vacant capsules shells and 6 lots gelatin were determined.Conclusions:The method is wide adaptable,which can be used in the determination of chromium in capsules,capsules shells and gelatin.The results from two different digestion conditions were basically the same.