卡马西平、左乙拉西坦单药治疗对癫痫部分性发作患儿脑电图的影响 |
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引用本文: | 张兰,陶拉娣,郑岚婷,庞欢欢. 卡马西平、左乙拉西坦单药治疗对癫痫部分性发作患儿脑电图的影响[J]. 中国医疗前沿, 2012, 0(8): 8-9,14 |
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作者姓名: | 张兰 陶拉娣 郑岚婷 庞欢欢 |
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作者单位: | 山西医科大学附属儿童医院神经内科 |
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摘 要: | 目的观察左乙拉西坦(LEV)和卡马西平(CBZ)单药治疗对癫痫部分性发作患儿脑电图的影响。方法选取符合诊断标准的癫痫患儿80例,随机分2组,LEV组和CBZ组各40例,于治疗前及治疗后每3个月复查一次脑电图,观察治疗前后脑电图的变化。结果治疗后两组间临床发作控制比较无差异(P=0.68),治疗后两组间脑电图痫样放电比较,CBZ组痫样放电完全消失7例,减少50%以上7例,减少25%-49%11例,无变化8例,增加7例,LEV组痫样放电完全消失21例,减少50%以上7例,减少25%-49%6例,无变化3例,增加3例。两组差异有统计学意义(P=0.001)。结论 LEV作为一种新型抗癫痫药物,在改善脑电图方面具有明显的优势,在治疗小儿癫痫部分性发作方面具有广大的应用前景。
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关 键 词: | 左乙拉西坦 卡马西平 脑电图 部分性发作 儿童癫痫 |
Changes of electroencephalogram in children with partial seizures treated by Carbamazepine and Levetiracetam as monotherapy |
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Affiliation: | ZHANG Lan,TAO La-di,ZHENG Lan-ting,et al.Department of Neurology in Shanxi Children’s Hospital,Taiyuan 030001,China |
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Abstract: | Objective To observe the changes of electroencephalogram(EEG) in children with partial seizures treated with Carbamazepine or Levetiracetam.Methods Choose 80 children diagnosed with partial seizures and randomly divided into 2 groups,every group 40 children.Carbamazepine and Levetiracetam are used respectively for the two groups.And their EEGs are examined before therapy and every 3 months after therapy and the attention is paid to the changes.Results Clinical controls over seizures are not significantly different between the two groups(P =0.68),but the epileptic discharges is obviously different(P =0.001): for the CBZ group,the epileptic discharges in 7 children disappear,7 decrease more than 50%,11 decrease 25%-49%,8 show no changes in epileptic discharges and 7 increase.While for the LEV group,the epileptic discharges in 21 children disappear,7 decrease more than 50%,6 decrease 25%-49%,3 show no changes in epileptic discharges and 3 increase.Conclusion LEV can significantly decrease the epileptic discharges on EEG.As a new anti-epileptic drug,LEV has a promising future in clinical use for treating children with partial seizures. |
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Keywords: | Levetiracetam Carbamazepine Electroencephalogram Partial seizures Children with epilepsy |
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