关于脂联素与易损斑块相关性的研究进展

所谓易损斑块是指易于破裂的高风险斑块,有别于引起管腔狭窄,导致稳定型心绞痛的斑块。此种斑块具有独特的组织学特性,由脂质核心、薄纤维帽等构成,并伴有血管壁的正性重构。而脂联素是一种脂肪因子,几乎参与到了从易损斑块形成至破裂的全部过程。目前更有大量研究指出,血清脂联素水平的降低同日益增长的冠状动脉疾病尤其是急性冠状动脉综合征的发病率密切相关。脂联素能够解释冠状动脉疾病病理进程中所涉及的炎症及动脉粥样硬化机制。

Research Linking Adiponectin and Vulnerable Atherosclerotic Plaque

The so-called vulnerable plaques are high-risk plaques that are characterized by their vulnerability to rupturing.They have distinct morphological characteristics which consist of a necrotic core,thin-inflamed fibrous caps,and are accompanied by positive remodeling.Adiponectin is a kind of adipocytokine which is involved in the rupture of vulnerable plaques.Furthermore,many studies indicate that hypoadiponectinemia is associated with an increased risk of coronary artery disease and acute coronary syndrome.T...