检测血清IGF-1和IGFBP-3对儿童生长激素缺乏症的诊断价值

目的：探讨血清胰岛素样生长因子-1(IGF-1)和胰岛素样生长因子结合蛋白-3(IGFBP-3)浓度在诊断生长激素缺乏症(GHD)患儿中的应用价值。方法：用免疫放射分析检测38例GHD患儿和42例对照儿童的血清IGF-1和IGFBP-3，同时进行生长激素(GH)激发试验，用化学发光法检测GH，对两组结果进行比较。结果：GHD组患儿IGF-1和IGFBP-3均显著低于对照组儿童，且在GH激发试验中，GH的增加值也明显低于对照组。结论：检测血清中的IGF-1和IGFBP-3，对诊断GHD儿童具有重要价值。

Diagnostic Value of Measurement of Serum Levels of Insulin-Like Growth Factor l (IGF-1) and IGF Binding Protein 3(IGFBP-3) for Children with Growth Hormone Deficiency (GHD)

Objective To appraise the feasibility of establishment of diagnosis of GHD with determination of serum IGF-1 and IGFBP-3 levels. Methods Serum IGF-1 and IGFBP-3 levels were measured with IRMA in 38 children with GHD and 42 controls. GH releasing stimalation test was also performed in these subjects with GH amount measured by chemiluminescence immunoassay (CLIA) for contrast study and verification of the diagnosis. Results In children with GHD, the serum IGF-1 and IGFBP-3 levels were significantly lower than those in the controls ( p <0 01). The amount of GH increased in the test was also significantly less. Conclusion Determination of serum levels of IGF-1 and IGFBP-3 can be used for the diagnosis of GHD in children, which may replace the traditional GH releasing stimulation test saving the children from repeated blood withdrawl.