血管回声跟踪技术评价长期吸烟人群不同尼古丁依赖程度下颈动脉弹性功能

目的探讨血管回声跟踪技术（E—trackingtechnology，ET）评价长期吸烟人群不同尼古丁依赖程度下颈动脉弹性功能的应用价值。方法对烟龄15～25年的长期吸烟人群进行尼古丁依赖问卷调查，按尼古丁依赖程度分为轻度依赖组、中度依赖组、重度依赖组三组，每组随机选取50例，正常对照组50例，应用ET技术对颈动脉血流动力学进行量化分析，评估动脉硬化参数，包括僵硬度（β）、压力-应变弹性系数（Ep）、动脉顺应性（AC）、血管收缩期内径（Ds）、血管舒张期内径（Dd）。结果β和Ep长期吸烟各组均高于正常对照组，差异有统计学意义（P〈0．01）；各不同尼古丁依赖组间差异有统计学意义（P〈0.05）；AC长期吸烟各组均显著低于正常对照组，差异有统计学意义（P〈0．01）；各不同尼古丁依赖组间差异无统计学意义（P〉0．05）；Ds和Dd各组间差异均无统计学意义（P〉0．05）。结论ET可早期发现吸烟人群血管内皮功能的改变，并能直观反映尼古丁依赖程度与血管内皮功能改变程度间的相关性，其具有无创、测量结果精确、操作便捷等临床优势。

Vessel wall echo - tracking evaluation of long - term smokers dependent on nicotine under different carotid artery elasticity

Objective To explore the value of E - tracking technology evaluate the long - term smokers dependent on nicotine under different carotid artery elasticity of application. Methods smoked 15 to 25 years of long - term smokers to nicotine dependence questionnaire, according to nicotine dependence group was divided into mild dependence, moderate depend- ence group, severe dependence group three groups, each group then selected 50 cases, normal control group of 50 patients, application of ET technology to quantify carotid artery blood flow velocity analysis to assess atheroselerosis parameters,including stiffness （ 3 ） , pressure - strain elastic modulus （ Ep ） , arterial compliance （ AC ） , systolic blood vessel diameter （ Ds ） , vascular diastolic diameter （Dd）. Results 3 and Ep long - term smoking groups were higher than the control group, the difference was statistically significant（ P 〈 0.01 ）, various nicotine dependence difference between the groups was statistically significant （P 〈 0. 05 ） ; AC long - term smoking of group were significantly lower than the control group, the difference was statistically significant （ P 〈 0. 01 ）, various nicotine dependence was no significant difference between the groups （ P 〉 0. 05 ） ; Ds and Dd the difference between the groups were not statistically significant （ P 〉 0. 05 ）. Conclusion ET the early detection of endothelial dysfunction in smokers changed, and could directly reflect the degree of nicotine dependence and endothelial dysfunction in the correlation between the degree of change, which had a non - invasive, accurate measurement, easy operation and other clinical advantages.