| 吉西他滨或培美曲塞联合顺铂治疗晚期非小细胞肺癌的临床比较研究 |
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| 引用本文： | 吴尉,朱跃红,袁志军,罗以. 吉西他滨或培美曲塞联合顺铂治疗晚期非小细胞肺癌的临床比较研究[J]. 临床和实验医学杂志, 2010, 9(8): 576-577 |
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| 作者姓名： | 吴尉 朱跃红 袁志军 罗以 |
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| 作者单位： | 湖南省肿瘤医院内二科,湖南,长沙,410013 |
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| 摘 要： | 目的比较吉西他滨或培美曲塞联合顺铂治疗晚期非小细胞肺癌（NSCLC）的临床疗效及毒副作用。方法将29例晚期NSCLC随机分为吉西他滨加顺铂组（GC）15例和培关曲塞加顺铂组（PC）14例。GC组吉西他滨1250mg／m^2，d1，8；顺铂75mg／m^2，d1～3。PC组培关曲塞500mg／m^2，d1；顺铂75mg／m^2，d1～3，两组均为每21d一个周期重复。结果吉西他滨加顺铂组和培美曲塞加顺铂组有效率分别为46．7％和42．9％，两组之间有效率无统计学意义（P〉0．05）。培美曲塞加顺铂组粒细胞减少的发生率小于吉西他滨加顺铂组。结论培美曲塞联合顺铂治疗晚期非小细胞肺癌的疗效与吉西他滨加顺铂的疗效相当．但副作用明显减少．可以作为临床一线治疗．
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| 关 键 词： | 非小细胞肺癌 化疗 吉西他滨 培美曲塞 |
Efficacy and toxicity of pemetrexed or gemcitabine plus cisplatin in treatment of patients with non-small cell lung cancer |
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| WU Wei,ZHU Yue-hong,YUAN Zhi-jun,et al.. Efficacy and toxicity of pemetrexed or gemcitabine plus cisplatin in treatment of patients with non-small cell lung cancer[J]. Journal of Clinical and Experimental Medicine, 2010, 9(8): 576-577 |
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| Authors: | WU Wei ZHU Yue-hong YUAN Zhi-jun et al. |
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| Affiliation: | WU Wei,ZHU Yue-hong,YUAN Zhi-jun,et al.Hunan Tumor Hospital,Changsha Hunan 410013,China |
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| Abstract: | Objective To observe the efficacy and toxicity of pemetrexed or gemcitabine plus cisplatin in treatment of patients with non-small cell lung cancer(NSCLC).Methods Twenty nine patients with late stage NSCLC were enrolled into this study.These patients were divided into GC(gemcitabine plus cisplatin)group(15 patients)and PC(pemetrexed plus cisplatin)group(14 patients)(GC:gemcitabine500mg/m2 plus cisplatin 75mg/m2,PC:pemetrexed 500mg/m2 plus cisplatin 75mg/m2).The efficacy of patients received two or more cycl... |
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| Keywords: | Non-small cell lung cancer Drug therapy Gemcitabine Pemetrexed |
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